Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4707932..4708448 Replicon chromosome
Accession NZ_CP047283
Organism Klebsiella quasipneumoniae strain N18-04116

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag F3137_RS22755 Protein ID WP_004206511.1
Coordinates 4707932..4708216 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag F3137_RS22760 Protein ID WP_002886901.1
Coordinates 4708206..4708448 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3137_RS22740 4702974..4704629 + 1656 WP_004206514.1 alpha,alpha-phosphotrehalase -
F3137_RS22745 4705015..4707153 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
F3137_RS22750 4707464..4707928 + 465 WP_004206512.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
F3137_RS22755 4707932..4708216 - 285 WP_004206511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F3137_RS22760 4708206..4708448 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F3137_RS22765 4708526..4710436 - 1911 WP_004206509.1 BglG family transcription antiterminator -
F3137_RS22770 4710459..4711610 - 1152 WP_004206508.1 lactonase family protein -
F3137_RS22775 4711678..4712418 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11163.01 Da        Isoelectric Point: 10.4599

>T145799 WP_004206511.1 NZ_CP047283:c4708216-4707932 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCDKIKLKASGYRLVYQVRDRVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T145799 NZ_CP062699:1763690-1764331 [Pseudomonas taiwanensis]
ATGATTTATTCCAGTCTCAACCCATCCAAGGCACTCATCTGGCGAATTGTTCACCGCGATAACCTGTCGTGGGTTCTGGA
TCATGGGCTGCACGCTGTCTCCTCCGGGAAGCTTTCCAGCACCTATGTTGGAATTGGCAATCCAGAGCTGATCAGCAAGC
GAGCGCAACGCCGTGTGCCTCTGGAACCCAATGGGACGCTGGCGGATTATGTACCGTTCTATTTCACCCCGTTCTCCGTG
ATGATGAAGAATATTCATTCGGGGTGGGGTGTTCCTCAGCGGCGGAACGAAGAGATCGTGATTCTTGTCTCCAGCCTGTA
CCATGCGCAGTCGCTGGGTTTGCAGTTTGTGTTCACGGATGCCCATGCCTACCCGCATTGGGCCGGCTACTACAGTAACC
TCACGCAGCTGGACAAAATCGATTGGGAGATTTTGCAGCGCAGGGATTTCAAACGTGACCCTGATGACCCTCGGAAAATG
GAGCGTTATCAGGCGGAGGCCCTTATCCATGGACATGTCCCAGTTGCTGCCCTTCTGGGAATTGTCTGCTACAACGAAGC
TTTGAAGGGGCGTGTCGACAAGGAGGTTCAGCAACGTCGATTGAATCTCCCTGTGTATGCTCGTCCTGGGTGGTACTTCT
AA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT145799 WP_002886901.1 NZ_CP047283:c4708448-4708206 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT145799 NZ_CP062699:1764331-1765419 [Pseudomonas taiwanensis]
ATGATCCACTTTATGCAAGGTAACCTGCTGGAGGCCAAGGCCGAAGCGCTGGTTAACACAGTTAACACCGTAGGGGTGAT
GGGGAAAGGCATCGCGCTGATGTTCAAGGAGCGTTTTGTCGAGAACTATCGCCAGTATGCTGCTGCCTGCAAAGCGAAAG
AGGTAGTTACCGGGAAGATGTTTGTTACTGAAGTGCGTGAGCTGGACGGTCCACGCTGGATTGTGAATTTTCCAACCAAG
CGGCATTGGCGCTCACCTTCGCAAATCGGCTGGATCGTCGAGGGCCTTCATGATTTGCGCAACTTCATTATCAATAACCA
GGTGGCATCGATTGCTATCCCTCCACTTGGTGCTGGTAATGGAGGGTTGTCTTGGGCTGCGGTACGAGAACAGATTCAGA
GGGTTCTGGGTGATCTGGACGCGGATGTTTTCGTTTTCGAGCCTACGGCAAATTATCAAAACGTTTCCAAGCGCAGTGGT
GTTGAGGTTTTGACCCCGGCTCGAGCCTTGATTGCAGAGCTTGTGCGCCGCTATTGGGTGCTGGGGATGGAGTGCAGCTT
GCTCGAAGTCCAGAAGCTTGCCTGGTTTCTGGAGCGATCAATCGAGCGGTTCACGCCAGGCATCAACCCATTGGAATTGA
AGTTTGTCGCTCATAAGTATGGTCCTTACGCCAACCGGCTTGAGCACCTGCTAGATAACCTGGATGGCAGCTATTTACAC
TGCCGAAAGCGGATCAGCGATGCAGGCCCTCTGGACGTTATCTGGTTTGATGAGGGGCGCAAGTCATTTTTACAGGCGTA
TCTGAACAGTGAAGCCAAGGCCTATTTGCCGGCGTTGGAGTTCACTGCCGAGTTGATTGATGGTTTCGAGTCTCCGTTTG
GTATGGAGCTGCTGGCCACCGTTGATTGGTTATTGCATGAAGATGGTGTTGAGCCGACAGTCCCTGCAGTTCGCGAACAC
CTGAAAAATTGGTCAGGAGGGGTAGGTGCCGCTGCTCGAAAAAGCAAACTGTTCGATGACGAGGCACTTGGAATCGCTCT
TCAAAAGCTGTCAATGTTTCGATCCGACCCAGCCACCTCGCTTCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References