Detailed information of TA system TA145798

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 4606693..4607396
• Replicon: chromosome
• Accession: NZ_CP047283
• Organism: Klebsiella quasipneumoniae strain N18-04116

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A8T6QFJ5
• Locus tag: F3137_RS22270
• Protein ID: WP_024360470.1
• Coordinates: 4606693..4607034 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: F3137_RS22275
• Protein ID: WP_183468358.1
• Coordinates: 4607055..4607396 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3137_RS22265	4605422..4606429	-	1008	WP_183468356.1	restriction endonuclease	-
F3137_RS22270	4606693..4607034	-	342	WP_024360470.1	TA system toxin CbtA family protein	Toxin
F3137_RS22275	4607055..4607396	-	342	WP_183468358.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
F3137_RS22280	4607407..4607949	-	543	WP_183468360.1	DNA repair protein RadC	-
F3137_RS22285	4607962..4608402	-	441	WP_183468362.1	antirestriction protein	-
F3137_RS22290	4608433..4609254	-	822	WP_183468364.1	DUF945 domain-containing protein	-
F3137_RS22295	4609369..4609842	-	474	WP_183468366.1	hypothetical protein	-
F3137_RS22300	4609914..4610366	-	453	WP_023227818.1	hypothetical protein	-
F3137_RS22305	4610402..4611118	-	717	WP_183468368.1	WYL domain-containing protein	-
F3137_RS22310	4611362..4612237	-	876	WP_183468370.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4601437..4659792	58355

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (13-111)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12793.70 Da
• Isoelectric Point: 8.4941

>T145798 WP_024360470.1 NZ_CP047283:c4607034-4606693 [Klebsiella quasipneumoniae]
MKTLPATNPQAATLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Nucleotide

• Length: 342 bp

>T145798 NZ_CP062699:c1147023-1146670 [Pseudomonas taiwanensis]
ATGCGGGTCATAACGAAAGCGGCGGTAACCAAGGCGATTGAAGCCCACGGCCAGTGGAAAGCGCCCCTAAGCCTGTGGCT
GACGACCTTCGACAGGGCGACGCTGCGGTTTGAATCTTTTGAACAGTTGAGGCAGACGTGGGTCACTGTGTCTGGCTGGA
ATGTTGATCGCATCCCCCACTCAAAACTTAGGCCCGCCAGCCGCAAAGGGCCGCTTGATATCTACGTGTTCGATATCAAG
AAAAACGAATGCCGCCTGATCGCGTGGCTCAATGCGCGAACGGGCACTCTCTACATCAAGGCCATTCTGTCGCACGCCGA
GTACGACAAATGGTGCAGAAGCGATATCAGGTAG

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12797.34 Da
• Isoelectric Point: 5.9577

>AT145798 WP_183468358.1 NZ_CP047283:c4607396-4607055 [Klebsiella quasipneumoniae]
MNSTDSENDSFLKWGLNCNMTSCFGARLVQEGNRLHYLADRACITGEFSNAESLKLDEVFTRFIRQMESMLTTGEMNPRH
AHSVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Nucleotide

• Length: 342 bp

>AT145798 NZ_CP062699:c1146628-1146155 [Pseudomonas taiwanensis]
ATGAAGCGGGATAAAATCGAAGCCAATGGACTAGATGCCTTCATCGCTAATATTTCACCCATGCTCGATGGCCTGAACAC
TCAGATGGCAACCATGGCCCAGCTTCTAGCCGCCTGCCATGACCCCATCAAGGACGATGCCGAGCTTGAGGCACGCATGG
CATTGATCGACGAGCTCTACTCCCATGCGGACAGCGAAGGCCACGCTGCGGCACGCTTTGCCGAGATGGTAGCGGACCGC
GTCTACGAGTATGAGAGTGAGTCTGTATTGGTGCCGTTCGCGAGCCAGGCCGAAGCGTTGGCCTTTCTGCTGTCGGACAG
GGGCGTGAAGCAGAAGGACCTGTCGGCGATAGCGACCCAGAGCGCGGTATCCGAGATTCTGAACAACAAGCGGAAGATGA
CGGTTGCCCAGATAAAGGGCTTTGCTGAGTTTTTCAGCGTACCGGTTGAGTTCTTCATGCATGGGGTGGTTTGA