Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3922994..3923613 Replicon chromosome
Accession NZ_CP047283
Organism Klebsiella quasipneumoniae strain N18-04116

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag F3137_RS19065 Protein ID WP_002892050.1
Coordinates 3923395..3923613 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag F3137_RS19060 Protein ID WP_002892066.1
Coordinates 3922994..3923368 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3137_RS19050 3918147..3919340 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
F3137_RS19055 3919363..3922509 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit -
F3137_RS19060 3922994..3923368 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
F3137_RS19065 3923395..3923613 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
F3137_RS19070 3923772..3924338 + 567 WP_004204750.1 maltose O-acetyltransferase -
F3137_RS19075 3924310..3924432 - 123 WP_032426076.1 hypothetical protein -
F3137_RS19080 3924475..3924945 + 471 WP_004204751.1 YlaC family protein -
F3137_RS19085 3924914..3926371 - 1458 WP_032455644.1 PLP-dependent aminotransferase family protein -
F3137_RS19090 3926472..3927170 + 699 WP_060656954.1 GNAT family N-acetyltransferase -
F3137_RS19095 3927167..3927307 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
F3137_RS19100 3927307..3927570 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T145797 WP_002892050.1 NZ_CP047283:3923395-3923613 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T145797 NZ_CP062699:c494145-493852 [Pseudomonas taiwanensis]
ATGTTTCTCGTTGAACAGACGGAAAGCTTTGCCGCTTGGCTATCGAGCTTGAGAGATTTGAGTGCCAGGCTGGCGATAGG
TCGTAGGCTGGAGCGAGCAGCGGCGGGCAATCTTGGTGACTTCAAGTGGCTTGGAGGCGGTATTGGTGAGCTTCGCATCG
ACGTAGCTGCCGGTTATCGCGTCGATTTCACGCAAAAGGGGCAGAGGTTGGTTTTACTGCTGGTCGGCGGCGACAAGTCC
ACCCAGGCCGCCGACATCCTCAAAGCCAGAAAGCTGCTGAAGGAGATGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT145797 WP_002892066.1 NZ_CP047283:3922994-3923368 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT145797 NZ_CP062699:c493855-493559 [Pseudomonas taiwanensis]
ATGAGCGAAAAATTGATCCCGTTTGATATGGCAGCCTTGTTGAGCAGCGATGAGGCAATCAGTGAATACCTTAGCCAGGT
GCTATCAAATGGCGATACCGAGGAAATCATTCGAGCACTTGGCCATATCGCTCGTGCACGGGGCATGACACATATTGCTA
CGGAGAGTGGGCTGGGTAGAGAAAGCCTGTACAAGGCGCTGAGCCCTGGCGCGAAGCCTCGTTTTGACACTGTATTGAGG
GTCATTCGTGCTCTGGGGGTGGACCTTCTCGTTCAGCCACATGCAATGACCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References