Detailed information of TA system TA145796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2629356..2630944
• Replicon: chromosome
• Accession: NZ_CP047283
• Organism: Klebsiella quasipneumoniae strain N18-04116

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: F3137_RS12910
• Protein ID: WP_004205919.1
• Coordinates: 2629356..2630678 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2A5MFC9
• Locus tag: F3137_RS12915
• Protein ID: WP_004205921.1
• Coordinates: 2630678..2630944 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3137_RS12875	2624438..2624656	+	219	WP_002904808.1	ParD-like family protein	-
F3137_RS12880	2624637..2625419	+	783	WP_023289670.1	type I methionyl aminopeptidase	-
F3137_RS12885	2625688..2626803	+	1116	WP_004205914.1	serine hydrolase	-
F3137_RS12890	2626790..2627134	+	345	WP_004205915.1	hypothetical protein	-
F3137_RS12895	2627163..2627696	+	534	WP_004205916.1	hypothetical protein	-
F3137_RS12900	2627699..2627905	+	207	WP_004205917.1	helix-turn-helix transcriptional regulator	-
F3137_RS12905	2628047..2629339	+	1293	WP_004205918.1	glycoside hydrolase family 10 protein	-
F3137_RS12910	2629356..2630678	-	1323	WP_004205919.1	type II toxin-antitoxin system HipA family toxin	Toxin
F3137_RS12915	2630678..2630944	-	267	WP_004205921.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
F3137_RS12920	2631227..2631553	-	327	WP_017900379.1	hydroxyisourate hydrolase	-
F3137_RS12925	2631550..2632050	-	501	WP_080846687.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
F3137_RS12930	2632028..2633407	-	1380	WP_136085014.1	purine permease	-
F3137_RS12935	2633753..2634907	+	1155	WP_004205928.1	FAD-dependent urate hydroxylase HpxO	-
F3137_RS12940	2634888..2635811	-	924	WP_004205929.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49013.27 Da
• Isoelectric Point: 8.2655

>T145796 WP_004205919.1 NZ_CP047283:c2630678-2629356 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLQAG

Nucleotide

• Length: 1323 bp

>T145796 NZ_CP062699:c493855-493559 [Pseudomonas taiwanensis]
ATGAGCGAAAAATTGATCCCGTTTGATATGGCAGCCTTGTTGAGCAGCGATGAGGCAATCAGTGAATACCTTAGCCAGGT
GCTATCAAATGGCGATACCGAGGAAATCATTCGAGCACTTGGCCATATCGCTCGTGCACGGGGCATGACACATATTGCTA
CGGAGAGTGGGCTGGGTAGAGAAAGCCTGTACAAGGCGCTGAGCCCTGGCGCGAAGCCTCGTTTTGACACTGTATTGAGG
GTCATTCGTGCTCTGGGGGTGGACCTTCTCGTTCAGCCACATGCAATGACCCGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9940.38 Da
• Isoelectric Point: 7.1997

>AT145796 WP_004205921.1 NZ_CP047283:c2630944-2630678 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT145796 NZ_CP062699:c494145-493852 [Pseudomonas taiwanensis]
ATGTTTCTCGTTGAACAGACGGAAAGCTTTGCCGCTTGGCTATCGAGCTTGAGAGATTTGAGTGCCAGGCTGGCGATAGG
TCGTAGGCTGGAGCGAGCAGCGGCGGGCAATCTTGGTGACTTCAAGTGGCTTGGAGGCGGTATTGGTGAGCTTCGCATCG
ACGTAGCTGCCGGTTATCGCGTCGATTTCACGCAAAAGGGGCAGAGGTTGGTTTTACTGCTGGTCGGCGGCGACAAGTCC
ACCCAGGCCGCCGACATCCTCAAAGCCAGAAAGCTGCTGAAGGAGATGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2A5MFC9