Detailed information of TA system TA145787

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1419566..1420349
• Replicon: chromosome
• Accession: NZ_CP047283
• Organism: Klebsiella quasipneumoniae strain N18-04116

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: F3137_RS06940
• Protein ID: WP_023318830.1
• Coordinates: 1419566..1419940 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: F3137_RS06945
• Protein ID: WP_023318829.1
• Coordinates: 1419990..1420349 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3137_RS06920	1414747..1415037	-	291	WP_050558920.1	GGDEF domain-containing protein	-
F3137_RS06925	1415056..1416084	-	1029	WP_050558921.1	MASE4 domain-containing protein	-
F3137_RS06930	1416697..1417511	-	815	Protein_1352	DUF4942 domain-containing protein	-
F3137_RS06935	1418038..1419027	+	990	WP_023318833.1	glycosyltransferase	-
F3137_RS06940	1419566..1419940	-	375	WP_023318830.1	TA system toxin CbtA family protein	Toxin
F3137_RS06945	1419990..1420349	-	360	WP_023318829.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
F3137_RS06950	1420372..1420593	-	222	WP_023318828.1	DUF987 domain-containing protein	-
F3137_RS06955	1420607..1421089	-	483	WP_032733401.1	DNA repair protein RadC	-
F3137_RS06960	1421330..1421809	-	480	WP_023318825.1	antirestriction protein	-
F3137_RS06965	1421889..1422710	-	822	WP_023318824.1	DUF945 domain-containing protein	-
F3137_RS06970	1422816..1423028	-	213	WP_023318823.1	hypothetical protein	-
F3137_RS06975	1423104..1423385	-	282	Protein_1361	hypothetical protein	-
F3137_RS06980	1423533..1423997	-	465	WP_032431255.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1415056..1435919	20863

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-112)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14050.26 Da
• Isoelectric Point: 10.2271

>T145787 WP_023318830.1 NZ_CP047283:c1419940-1419566 [Klebsiella quasipneumoniae]
MQIHSLYLQRAASSRLSSVEIWRKLLKYLLKQHYGLMLNDTPFGNDEVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSIDMLRARKATGLMTRKGYKTVTDITGGRFSGGK

Nucleotide

• Length: 375 bp

>T145787 NZ_CP062497:c1344247-1343501 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTATATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTAGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAGCCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13441.57 Da
• Isoelectric Point: 7.3239

>AT145787 WP_023318829.1 NZ_CP047283:c1420349-1419990 [Klebsiella quasipneumoniae]
MQKATRVINHNITEPWWGLRRNITPCFGARLVQEGNHLHYLADRASIAGTFNDADLRHLDQVFPVLMKQMELMLASSELT
PRIQRCITLHVKGLICEADTLGSCGYLYIVIYPASATTE

Nucleotide

• Length: 360 bp

>AT145787 NZ_CP062497:c1343501-1343331 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA