Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 788369..789026 Replicon chromosome
Accession NZ_CP047283
Organism Klebsiella quasipneumoniae strain N18-04116

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag F3137_RS03880 Protein ID WP_004205323.1
Coordinates 788616..789026 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag F3137_RS03875 Protein ID WP_002916312.1
Coordinates 788369..788635 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3137_RS03850 783578..785011 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
F3137_RS03855 785130..785858 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
F3137_RS03860 785908..786219 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
F3137_RS03865 786382..787041 + 660 WP_004205319.1 hemolysin III family protein -
F3137_RS03870 787140..788123 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
F3137_RS03875 788369..788635 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
F3137_RS03880 788616..789026 + 411 WP_004205323.1 protein YgfX Toxin
F3137_RS03885 789033..789554 - 522 WP_004205324.1 flavodoxin FldB -
F3137_RS03890 789655..790551 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
F3137_RS03895 790574..791287 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F3137_RS03900 791293..793026 + 1734 WP_136084845.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T145786 WP_004205323.1 NZ_CP047283:788616-789026 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T145786 NZ_CP062497:510537-510887 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT145786 WP_002916312.1 NZ_CP047283:788369-788635 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT145786 NZ_CP062497:510251-510532 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References