Detailed information of TA system TA145783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4755515..4756031
• Replicon: chromosome
• Accession: NZ_CP047281
• Organism: Klebsiella quasipneumoniae strain N18-04101

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F3109_RS23165
• Protein ID: WP_183473099.1
• Coordinates: 4755515..4755799 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: F3109_RS23170
• Protein ID: WP_002886901.1
• Coordinates: 4755789..4756031 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3109_RS23150	4750626..4752281	+	1656	WP_106939517.1	alpha,alpha-phosphotrehalase	-
F3109_RS23155	4752667..4754805	+	2139	WP_183473098.1	anaerobic ribonucleoside-triphosphate reductase	-
F3109_RS23160	4755047..4755511	+	465	WP_032456904.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
F3109_RS23165	4755515..4755799	-	285	WP_183473099.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F3109_RS23170	4755789..4756031	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
F3109_RS23175	4756109..4758019	-	1911	WP_057212387.1	BglG family transcription antiterminator	-
F3109_RS23180	4758042..4759193	-	1152	WP_183473100.1	lactonase family protein	-
F3109_RS23185	4759260..4760000	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11211.10 Da
• Isoelectric Point: 10.4951

>T145783 WP_183473099.1 NZ_CP047281:c4755799-4755515 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T145783 NZ_CP062471:2505504-2505821 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT145783 WP_002886901.1 NZ_CP047281:c4756031-4755789 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT145783 NZ_CP062471:2505292-2505501 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0