Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4059476..4060095 Replicon chromosome
Accession NZ_CP047281
Organism Klebsiella quasipneumoniae strain N18-04101

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag F3109_RS19935 Protein ID WP_002892050.1
Coordinates 4059877..4060095 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag F3109_RS19930 Protein ID WP_002892066.1
Coordinates 4059476..4059850 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3109_RS19920 4054629..4055822 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
F3109_RS19925 4055845..4058991 + 3147 WP_017898892.1 multidrug efflux RND transporter permease subunit -
F3109_RS19930 4059476..4059850 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
F3109_RS19935 4059877..4060095 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
F3109_RS19940 4060253..4060819 + 567 WP_087832569.1 maltose O-acetyltransferase -
F3109_RS19945 4060791..4060913 - 123 WP_032431198.1 hypothetical protein -
F3109_RS19950 4060956..4061426 + 471 WP_049093338.1 YlaC family protein -
F3109_RS19955 4061395..4062852 - 1458 WP_179417060.1 PLP-dependent aminotransferase family protein -
F3109_RS19960 4062953..4063651 + 699 WP_064187826.1 GNAT family N-acetyltransferase -
F3109_RS19965 4063648..4063788 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
F3109_RS19970 4063788..4064051 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T145782 WP_002892050.1 NZ_CP047281:4059877-4060095 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T145782 NZ_CP062471:c1371852-1371586 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT145782 WP_002892066.1 NZ_CP047281:4059476-4059850 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT145782 NZ_CP062471:c1372109-1371852 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References