Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2620040..2621628 Replicon chromosome
Accession NZ_CP047281
Organism Klebsiella quasipneumoniae strain N18-04101

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag F3109_RS12885 Protein ID WP_069135995.1
Coordinates 2620040..2621362 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag F3109_RS12890 Protein ID WP_179416561.1
Coordinates 2621362..2621628 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3109_RS12860 2616863..2617111 + 249 WP_004205912.1 hypothetical protein -
F3109_RS12865 2617402..2617620 + 219 WP_002904808.1 ParD-like family protein -
F3109_RS12870 2617601..2618383 + 783 WP_049003659.1 type I methionyl aminopeptidase -
F3109_RS12875 2618473..2618589 + 117 Protein_2524 helix-turn-helix domain-containing protein -
F3109_RS12880 2618731..2620023 + 1293 WP_023318214.1 glycoside hydrolase family 10 protein -
F3109_RS12885 2620040..2621362 - 1323 WP_069135995.1 type II toxin-antitoxin system HipA family toxin Toxin
F3109_RS12890 2621362..2621628 - 267 WP_179416561.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
F3109_RS12895 2621911..2622237 - 327 WP_179416560.1 hydroxyisourate hydrolase -
F3109_RS12900 2622234..2622734 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
F3109_RS12905 2622712..2624091 - 1380 WP_183474409.1 purine permease -
F3109_RS12910 2624437..2625591 + 1155 WP_004205928.1 FAD-dependent urate hydroxylase HpxO -
F3109_RS12915 2625572..2626495 - 924 WP_106939111.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaOKP-B-15 mgtC / iroE 2450971..2872915 421944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49024.33 Da        Isoelectric Point: 8.2542

>T145781 WP_069135995.1 NZ_CP047281:c2621362-2620040 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAYLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLLAG

Download         Length: 1323 bp

>T145781 NZ_CP062471:c1340578-1340471 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9930.34 Da        Isoelectric Point: 7.1997

>AT145781 WP_179416561.1 NZ_CP047281:c2621628-2621362 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIS
DNTTDLDW

Download         Length: 267 bp

>AT145781 NZ_CP062471:1340394-1340454 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References