Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 823653..824310 Replicon chromosome
Accession NZ_CP047281
Organism Klebsiella quasipneumoniae strain N18-04101

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag F3109_RS04085 Protein ID WP_004205323.1
Coordinates 823900..824310 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag F3109_RS04080 Protein ID WP_002916312.1
Coordinates 823653..823919 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3109_RS04055 818810..820243 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
F3109_RS04060 820362..821090 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
F3109_RS04065 821140..821451 + 312 WP_106938698.1 N(4)-acetylcytidine aminohydrolase -
F3109_RS04070 821614..822273 + 660 WP_004205319.1 hemolysin III family protein -
F3109_RS04075 822424..823407 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
F3109_RS04080 823653..823919 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
F3109_RS04085 823900..824310 + 411 WP_004205323.1 protein YgfX Toxin
F3109_RS04090 824317..824838 - 522 WP_004205324.1 flavodoxin FldB -
F3109_RS04095 824939..825835 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
F3109_RS04100 825858..826571 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F3109_RS04105 826577..828310 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T145771 WP_004205323.1 NZ_CP047281:823900-824310 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T145771 NZ_CP062469:1014292-1014468 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT145771 WP_002916312.1 NZ_CP047281:823653-823919 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT145771 NZ_CP062469:c1014630-1014456 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References