Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tad-ata/COG5606-COG4679 |
Location | 4853262..4853928 | Replicon | chromosome |
Accession | NZ_CP047279 | ||
Organism | Citrobacter freundii strain N18-04128 |
Toxin (Protein)
Gene name | tad | Uniprot ID | A0A0D7LIM5 |
Locus tag | F3113_RS23660 | Protein ID | WP_044702260.1 |
Coordinates | 4853569..4853928 (-) | Length | 120 a.a. |
Antitoxin (Protein)
Gene name | ata | Uniprot ID | A0A0D7LIR0 |
Locus tag | F3113_RS23655 | Protein ID | WP_003844682.1 |
Coordinates | 4853262..4853579 (-) | Length | 106 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F3113_RS23625 | 4848929..4849753 | + | 825 | WP_003031641.1 | PTS system mannose/fructose/sorbose family transporter subunit IID | - |
F3113_RS23630 | 4849822..4851045 | + | 1224 | WP_044702265.1 | L-sorbose 1-phosphate reductase | - |
F3113_RS23635 | 4851047..4851859 | + | 813 | WP_044702264.1 | shikimate 5-dehydrogenase | - |
F3113_RS23640 | 4851911..4852267 | - | 357 | WP_032948294.1 | hypothetical protein | - |
F3113_RS23645 | 4852409..4852570 | + | 162 | WP_003841416.1 | phage protein | - |
F3113_RS23650 | 4852974..4853252 | + | 279 | WP_044702262.1 | putative addiction module antidote protein | - |
F3113_RS23655 | 4853262..4853579 | - | 318 | WP_003844682.1 | helix-turn-helix domain-containing protein | Antitoxin |
F3113_RS23660 | 4853569..4853928 | - | 360 | WP_044702260.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
F3113_RS23665 | 4854142..4854831 | + | 690 | WP_003841421.1 | dipeptidase PepE | - |
F3113_RS23670 | 4854897..4856528 | - | 1632 | WP_032938230.1 | Na/Pi cotransporter family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 120 a.a. Molecular weight: 13437.49 Da Isoelectric Point: 10.2555
>T145767 WP_044702260.1 NZ_CP047279:c4853928-4853569 [Citrobacter freundii]
MTKPLYWVGQARKDLIAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT
MTKPLYWVGQARKDLIAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT
Download Length: 360 bp
>T145767 NZ_CP062469:841656-841760 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11466.35 Da Isoelectric Point: 9.0005
>AT145767 WP_003844682.1 NZ_CP047279:c4853579-4853262 [Citrobacter freundii]
MSHDVETSSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG
MSHDVETSSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG
Download Length: 318 bp
>AT145767 NZ_CP062469:c841918-841755 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0D7LIM5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0D7LIR0 |