Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3881179..3881799 | Replicon | chromosome |
Accession | NZ_CP047279 | ||
Organism | Citrobacter freundii strain N18-04128 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | F3113_RS18915 | Protein ID | WP_002892050.1 |
Coordinates | 3881581..3881799 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | R8WZW8 |
Locus tag | F3113_RS18910 | Protein ID | WP_003021733.1 |
Coordinates | 3881179..3881553 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F3113_RS18900 | 3876328..3877521 | + | 1194 | WP_003835922.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
F3113_RS18905 | 3877544..3880693 | + | 3150 | WP_003021736.1 | multidrug efflux RND transporter permease subunit | - |
F3113_RS18910 | 3881179..3881553 | + | 375 | WP_003021733.1 | Hha toxicity modulator TomB | Antitoxin |
F3113_RS18915 | 3881581..3881799 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
F3113_RS18920 | 3882106..3882657 | + | 552 | WP_044699372.1 | maltose O-acetyltransferase | - |
F3113_RS18925 | 3882774..3883244 | + | 471 | WP_003021724.1 | YlaC family protein | - |
F3113_RS18930 | 3883323..3883463 | - | 141 | WP_005125190.1 | type B 50S ribosomal protein L36 | - |
F3113_RS18935 | 3883465..3883725 | - | 261 | WP_003021719.1 | type B 50S ribosomal protein L31 | - |
F3113_RS18940 | 3883914..3885467 | + | 1554 | WP_044699371.1 | EAL domain-containing protein | - |
F3113_RS18945 | 3885519..3885872 | - | 354 | WP_003831033.1 | DUF1428 family protein | - |
F3113_RS18950 | 3885937..3886566 | - | 630 | WP_003835929.1 | membrane protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T145764 WP_002892050.1 NZ_CP047279:3881581-3881799 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T145764 NZ_CP062469:199433-199528 [Staphylococcus aureus]
ATGGCAGATATTCTTGTTAATATCATGACCACGGCAGCAAGTGGTTGTATCGTCGCGTTGTTTTCATATTGGCTTCGAAA
ACGTGATGATAAATAG
ATGGCAGATATTCTTGTTAATATCATGACCACGGCAGCAAGTGGTTGTATCGTCGCGTTGTTTTCATATTGGCTTCGAAA
ACGTGATGATAAATAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 14427.23 Da Isoelectric Point: 5.5653
>AT145764 WP_003021733.1 NZ_CP047279:3881179-3881553 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT145764 NZ_CP062469:c199589-199553 [Staphylococcus aureus]
ATGCACCAATCCCCTCACTACTGCCATAGTGAGGGGA
ATGCACCAATCCCCTCACTACTGCCATAGTGAGGGGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | R8WZW8 |