Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 952241..952895 Replicon chromosome
Accession NZ_CP047279
Organism Citrobacter freundii strain N18-04128

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag F3113_RS04725 Protein ID WP_003026936.1
Coordinates 952488..952895 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag F3113_RS04720 Protein ID WP_003026938.1
Coordinates 952241..952507 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3113_RS04695 947442..948875 - 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -
F3113_RS04700 948996..949724 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
F3113_RS04705 949777..950088 + 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
F3113_RS04710 950251..950910 + 660 WP_003838267.1 hemolysin III family protein -
F3113_RS04715 951004..951984 - 981 WP_003026944.1 tRNA-modifying protein YgfZ -
F3113_RS04720 952241..952507 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
F3113_RS04725 952488..952895 + 408 WP_003026936.1 protein YgfX Toxin
F3113_RS04730 952940..953461 - 522 WP_003026933.1 flavodoxin FldB -
F3113_RS04735 953575..954471 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
F3113_RS04740 954495..955208 + 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F3113_RS04745 955214..956947 + 1734 WP_044700800.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T145755 WP_003026936.1 NZ_CP047279:952488-952895 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T145755 NZ_CP062467:1278154-1278420 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT145755 WP_003026938.1 NZ_CP047279:952241-952507 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT145755 NZ_CP062467:1277903-1278154 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References