145747

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4084853..4085667 Replicon chromosome
Accession NZ_CP047277
Organism Escherichia coli strain N18-04097

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag F3052_RS19645 Protein ID WP_001054376.1
Coordinates 4084853..4085110 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID B7MMJ3
Locus tag F3052_RS19650 Protein ID WP_001338189.1
Coordinates 4085122..4085667 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3052_RS19625 4080141..4081247 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
F3052_RS19630 4081312..4082292 + 981 WP_000991455.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
F3052_RS19635 4082875..4084115 - 1241 Protein_3849 DNA helicase -
F3052_RS19640 4084231..4084476 + 246 Protein_3850 GNAT family N-acetyltransferase -
F3052_RS19645 4084853..4085110 + 258 WP_001054376.1 hypothetical protein Toxin
F3052_RS19650 4085122..4085667 + 546 WP_001338189.1 N-acetyltransferase Antitoxin
F3052_RS19655 4085723..4086469 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
F3052_RS19660 4086638..4086856 + 219 Protein_3854 hypothetical protein -
F3052_RS24375 4086894..4087010 + 117 Protein_3855 VOC family protein -
F3052_RS19665 4087255..4088376 + 1122 WP_000010829.1 M42 family metallopeptidase -
F3052_RS19670 4088373..4088651 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
F3052_RS19675 4088663..4089976 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB 4076277..4093891 17614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T145747 WP_001054376.1 NZ_CP047277:4084853-4085110 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T145747 NZ_CP062465:966666-966842 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19986.92 Da        Isoelectric Point: 6.3277

>AT145747 WP_001338189.1 NZ_CP047277:4085122-4085667 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT145747 NZ_CP062465:c967004-966830 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2KXJ3

References