Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4873982..4874648 Replicon chromosome
Accession NZ_CP047273
Organism Citrobacter freundii strain N18-04078

Toxin (Protein)


Gene name tad Uniprot ID A0A0D7LIM5
Locus tag F3085_RS23690 Protein ID WP_044702260.1
Coordinates 4874289..4874648 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0D7LIR0
Locus tag F3085_RS23685 Protein ID WP_003844682.1
Coordinates 4873982..4874299 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3085_RS23655 4869649..4870473 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
F3085_RS23660 4870542..4871765 + 1224 WP_044702265.1 L-sorbose 1-phosphate reductase -
F3085_RS23665 4871767..4872579 + 813 WP_044702264.1 shikimate 5-dehydrogenase -
F3085_RS23670 4872631..4872987 - 357 WP_032948294.1 hypothetical protein -
F3085_RS23675 4873129..4873290 + 162 WP_003841416.1 phage protein -
F3085_RS23680 4873694..4873972 + 279 WP_044702262.1 putative addiction module antidote protein -
F3085_RS23685 4873982..4874299 - 318 WP_003844682.1 helix-turn-helix domain-containing protein Antitoxin
F3085_RS23690 4874289..4874648 - 360 WP_044702260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F3085_RS23695 4874862..4875551 + 690 WP_003841421.1 dipeptidase PepE -
F3085_RS23700 4875617..4877248 - 1632 WP_183274481.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13437.49 Da        Isoelectric Point: 10.2555

>T145700 WP_044702260.1 NZ_CP047273:c4874648-4874289 [Citrobacter freundii]
MTKPLYWVGQARKDLIAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

>T145700 NZ_CP062418:2649132-2649494 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11466.35 Da        Isoelectric Point: 9.0005

>AT145700 WP_003844682.1 NZ_CP047273:c4874299-4873982 [Citrobacter freundii]
MSHDVETSSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp

>AT145700 NZ_CP062418:2648965-2649135 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LIM5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7LIR0

References