Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4571851..4572367 Replicon chromosome
Accession NZ_CP047273
Organism Citrobacter freundii strain N18-04078

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag F3085_RS22140 Protein ID WP_044699148.1
Coordinates 4571851..4572135 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag F3085_RS22145 Protein ID WP_183273543.1
Coordinates 4572125..4572367 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3085_RS22125 4568176..4568760 + 585 WP_003839584.1 fructose PTS transporter subunit IIA -
F3085_RS22130 4569138..4571276 + 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
F3085_RS22135 4571383..4571847 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
F3085_RS22140 4571851..4572135 - 285 WP_044699148.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F3085_RS22145 4572125..4572367 - 243 WP_183273543.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F3085_RS22150 4572445..4574358 - 1914 WP_003839574.1 BglG family transcription antiterminator -
F3085_RS22155 4574380..4575120 - 741 WP_044699149.1 KDGP aldolase family protein -
F3085_RS22160 4575117..4576235 - 1119 WP_044699152.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
F3085_RS22165 4576219..4577352 - 1134 WP_016149471.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10865.69 Da        Isoelectric Point: 10.1988

>T145699 WP_044699148.1 NZ_CP047273:c4572135-4571851 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
RQHSAVYLDANKRL

Download         Length: 285 bp

>T145699 NZ_CP062418:2629531-2629740 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8947.32 Da        Isoelectric Point: 5.0651

>AT145699 WP_183273543.1 NZ_CP047273:c4572367-4572125 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNISPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT145699 NZ_CP062418:2629226-2629519 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References