Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 953522..954176 Replicon chromosome
Accession NZ_CP047273
Organism Citrobacter freundii strain N18-04078

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag F3085_RS04710 Protein ID WP_003026936.1
Coordinates 953769..954176 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag F3085_RS04705 Protein ID WP_003026938.1
Coordinates 953522..953788 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3085_RS04680 948723..950156 - 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -
F3085_RS04685 950277..951005 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
F3085_RS04690 951058..951369 + 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
F3085_RS04695 951532..952191 + 660 WP_003838267.1 hemolysin III family protein -
F3085_RS04700 952285..953265 - 981 WP_003026944.1 tRNA-modifying protein YgfZ -
F3085_RS04705 953522..953788 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
F3085_RS04710 953769..954176 + 408 WP_003026936.1 protein YgfX Toxin
F3085_RS04715 954221..954742 - 522 WP_003026933.1 flavodoxin FldB -
F3085_RS04720 954856..955752 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
F3085_RS04725 955776..956489 + 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F3085_RS04730 956495..958228 + 1734 WP_044700800.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T145688 WP_003026936.1 NZ_CP047273:953769-954176 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T145688 NZ_CP062417:2294969-2295076 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT145688 WP_003026938.1 NZ_CP047273:953522-953788 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT145688 NZ_CP062417:c2295153-2295093 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References