Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 63630..64351 Replicon chromosome
Accession NZ_CP047273
Organism Citrobacter freundii strain N18-04078

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag F3085_RS00325 Protein ID WP_047399350.1
Coordinates 63630..63971 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0A0FFR4
Locus tag F3085_RS00330 Protein ID WP_045265421.1
Coordinates 64007..64351 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3085_RS00290 59058..59432 - 375 WP_016151201.1 hypothetical protein -
F3085_RS00295 59838..60014 - 177 WP_044700470.1 hypothetical protein -
F3085_RS00300 60132..60422 - 291 WP_044700468.1 SymE family type I addiction module toxin -
F3085_RS00305 60559..60753 + 195 WP_044700466.1 toxin-antitoxin system HicB family antitoxin -
F3085_RS00310 60762..61328 - 567 WP_044700465.1 hypothetical protein -
F3085_RS00315 61557..62594 - 1038 WP_045265419.1 virulence RhuM family protein -
F3085_RS00320 62682..63515 - 834 WP_045265420.1 DUF4942 domain-containing protein -
F3085_RS00325 63630..63971 - 342 WP_047399350.1 TA system toxin CbtA family protein Toxin
F3085_RS00330 64007..64351 - 345 WP_045265421.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
F3085_RS00335 64375..64596 - 222 WP_045265422.1 DUF987 family protein -
F3085_RS00340 64607..65080 - 474 WP_045265423.1 DNA repair protein RadC -
F3085_RS00345 65151..65972 - 822 WP_183273566.1 DUF945 domain-containing protein -
F3085_RS00350 66044..66493 - 450 WP_045265425.1 hypothetical protein -
F3085_RS00355 66725..67528 - 804 WP_045265426.1 hypothetical protein -
F3085_RS00360 67548..67982 - 435 WP_045265427.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(14-113)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12748.67 Da        Isoelectric Point: 8.5196

>T145685 WP_047399350.1 NZ_CP047273:c63971-63630 [Citrobacter freundii]
MNTSPATNQRVAKPCPSPVAVWQMLLTRLLAQHYGLALSDTPFCDETVIQEHINAGVTLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQAMGLLRQGHNLSTR

Download         Length: 342 bp

>T145685 NZ_CP062417:c173392-173297 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12867.88 Da        Isoelectric Point: 8.1459

>AT145685 WP_045265421.1 NZ_CP047273:c64351-64007 [Citrobacter freundii]
MKKDTANEVVDTLRWGLKCDITPHFGARLVQEGNRLHYLADRASIIGPFSKADLRHLNQAFPLLMKQMELMLTSGELNSR
HQHCVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 345 bp

>AT145685 NZ_CP062417:173212-173269 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0A0FFR4

References