Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4749492..4750008 Replicon chromosome
Accession NZ_CP047271
Organism Klebsiella pneumoniae strain N16-03892

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag F3090_RS23465 Protein ID WP_009309309.1
Coordinates 4749492..4749776 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag F3090_RS23470 Protein ID WP_002886901.1
Coordinates 4749766..4750008 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3090_RS23440 4744976..4745284 - 309 WP_020079792.1 PTS sugar transporter subunit IIB -
F3090_RS23445 4745369..4745542 + 174 WP_032412860.1 hypothetical protein -
F3090_RS23450 4745545..4746288 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
F3090_RS23455 4746645..4748783 + 2139 WP_032442589.1 anaerobic ribonucleoside-triphosphate reductase -
F3090_RS23460 4749024..4749488 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
F3090_RS23465 4749492..4749776 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F3090_RS23470 4749766..4750008 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F3090_RS23475 4750086..4751996 - 1911 WP_023280782.1 BglG family transcription antiterminator -
F3090_RS23480 4752019..4753173 - 1155 WP_023280781.1 lactonase family protein -
F3090_RS23485 4753240..4753980 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T145678 WP_009309309.1 NZ_CP047271:c4749776-4749492 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T145678 NZ_CP062416:2310996-2311103 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT145678 WP_002886901.1 NZ_CP047271:c4750008-4749766 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT145678 NZ_CP062416:c2311180-2311120 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References