Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807746..808403 Replicon chromosome
Accession NZ_CP047271
Organism Klebsiella pneumoniae strain N16-03892

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag F3090_RS04020 Protein ID WP_002916310.1
Coordinates 807993..808403 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag F3090_RS04015 Protein ID WP_002916312.1
Coordinates 807746..808012 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3090_RS03990 802902..804335 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
F3090_RS03995 804454..805182 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
F3090_RS04000 805232..805543 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
F3090_RS04005 805707..806366 + 660 WP_002916317.1 hemolysin III family protein -
F3090_RS04010 806517..807500 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
F3090_RS04015 807746..808012 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
F3090_RS04020 807993..808403 + 411 WP_002916310.1 protein YgfX Toxin
F3090_RS04025 808410..808931 - 522 WP_004144730.1 flavodoxin FldB -
F3090_RS04030 809032..809928 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
F3090_RS04035 809951..810664 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F3090_RS04040 810670..812403 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T145665 WP_002916310.1 NZ_CP047271:807993-808403 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T145665 NZ_CP062415:c223055-222960 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT145665 WP_002916312.1 NZ_CP047271:807746-808012 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT145665 NZ_CP062415:222875-222932 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References