Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 5495422..5496020 Replicon chromosome
Accession NZ_CP047265
Organism Pseudomonas asturiensis strain CC1524

Toxin (Protein)


Gene name chpB Uniprot ID A0A7Z2R0K3
Locus tag N015_RS24625 Protein ID WP_024687830.1
Coordinates 5495422..5495769 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A7Z2R013
Locus tag N015_RS24630 Protein ID WP_024687831.1
Coordinates 5495766..5496020 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N015_RS24610 5490870..5492867 - 1998 WP_024687827.1 transketolase -
N015_RS24615 5493126..5494121 + 996 WP_024687828.1 metalloregulator ArsR/SmtB family transcription factor -
N015_RS24620 5494142..5495332 + 1191 WP_024687829.1 methionine adenosyltransferase -
N015_RS24625 5495422..5495769 - 348 WP_024687830.1 type II toxin-antitoxin system ChpB family toxin Toxin
N015_RS24630 5495766..5496020 - 255 WP_024687831.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
N015_RS24635 5496266..5497948 + 1683 WP_024687832.1 NAD-dependent DNA ligase LigB -
N015_RS24640 5498003..5498410 + 408 WP_024687833.1 DUF1090 domain-containing protein -
N015_RS24645 5498754..5499155 - 402 WP_024687834.1 MAPEG family protein -
N015_RS24650 5499251..5500642 - 1392 WP_024687835.1 heavy metal sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12249.00 Da        Isoelectric Point: 7.7922

>T145635 WP_024687830.1 NZ_CP047265:c5495769-5495422 [Pseudomonas asturiensis]
VKRPRFNRADIVRINLNPTAGREQQGDFRPALVLTPAAYNVSGLAIVAPITQGGDFARYAGFAVPLSGSGTETQGVVLCN
QIRTVDLEARGAKCIEAAPDVVINDVLARVQALFE

Download         Length: 348 bp

>T145635 NZ_CP062412:2311538-2311645 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9310.72 Da        Isoelectric Point: 4.4865

>AT145635 WP_024687831.1 NZ_CP047265:c5496020-5495766 [Pseudomonas asturiensis]
MEVKIQQWGNSAAIRLPANVLKQMSLVSGDVLVLDVSTDVMTLKPAKSRLHYRLADLMAQCDLDAAEPEELSDWNAMQPT
GREV

Download         Length: 255 bp

>AT145635 NZ_CP062412:c2311722-2311662 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2R0K3

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z2R013

References