145633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5945..6585 Replicon plasmid pPma4326A
Accession NZ_CP047262
Organism Pseudomonas syringae pv. maculicola str. ES4326

Toxin (Protein)


Gene name hicA Uniprot ID A0A0P9RJE6
Locus tag PMA4326_RS30180 Protein ID WP_007253326.1
Coordinates 5945..6127 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q6J2J7
Locus tag PMA4326_RS30185 Protein ID WP_005622461.1
Coordinates 6160..6585 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMA4326_RS30160 1514..1801 + 288 WP_004667956.1 HU family DNA-binding protein -
PMA4326_RS30165 2630..3091 + 462 WP_007253323.1 DUF4113 domain-containing protein -
PMA4326_RS30170 3427..3897 - 471 WP_007253324.1 hypothetical protein -
PMA4326_RS30175 4826..5314 + 489 Protein_4 hypothetical protein -
PMA4326_RS30180 5945..6127 + 183 WP_007253326.1 type II toxin-antitoxin system HicA family toxin Toxin
PMA4326_RS30185 6160..6585 + 426 WP_005622461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PMA4326_RS30190 7102..7464 + 363 WP_007253327.1 hypothetical protein -
PMA4326_RS30195 7637..8799 + 1163 WP_086004200.1 IS3 family transposase -
PMA4326_RS30200 9338..9541 - 204 WP_011178574.1 hypothetical protein -
PMA4326_RS30205 9618..10637 - 1020 WP_099982888.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..46546 46546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6822.93 Da        Isoelectric Point: 10.5498

>T145633 WP_007253326.1 NZ_CP047262:5945-6127 [Pseudomonas syringae pv. maculicola str. ES4326]
MKCSEFRRWLQAQGAEFKAAKGSHFKVYLNGKATIFADHGSKEMHEGLRKSIIKQLGLKD

Download         Length: 183 bp

>T145633 NZ_CP062412:c1613396-1613079 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15749.11 Da        Isoelectric Point: 4.7523

>AT145633 WP_005622461.1 NZ_CP047262:6160-6585 [Pseudomonas syringae pv. maculicola str. ES4326]
MYQYPLELHQEPTGIWLSCPDIPEMNASGDTLDEALAEALNGMESAFSLYVDQRRKIPQASLPSGDELVMHLPALTVAKI
MLWNSMLDNGVSRAELARRLSCTRQVVDRLVDFLHTSKIEQVERALAVLGRRITLSIEQAA

Download         Length: 426 bp

>AT145633 NZ_CP062412:c1613608-1613399 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P9RJE6

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3GLX7

References