145631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 3785523..3785968 Replicon chromosome
Accession NZ_CP047260
Organism Pseudomonas syringae pv. maculicola str. ES4326

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag PMA4326_RS17345 Protein ID WP_122320264.1
Coordinates 3785840..3785968 (-) Length 43 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0K8LSV9
Locus tag PMA4326_RS17340 Protein ID WP_004397562.1
Coordinates 3785523..3785843 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMA4326_RS17325 3780709..3782043 + 1335 WP_007250195.1 virulence factor family protein -
PMA4326_RS17330 3782136..3784031 - 1896 WP_054080062.1 potassium transporter Kup -
PMA4326_RS17335 3784337..3785428 + 1092 WP_007250193.1 catalase family protein -
PMA4326_RS17340 3785523..3785843 - 321 WP_004397562.1 helix-turn-helix domain-containing protein Antitoxin
PMA4326_RS17345 3785840..3785968 - 129 WP_122320264.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PMA4326_RS17350 3786250..3787593 + 1344 WP_007250191.1 30S ribosomal protein S12 methylthiotransferase RimO -
PMA4326_RS17355 3787710..3788150 + 441 WP_007250190.1 GNAT family N-acetyltransferase -
PMA4326_RS17360 3788244..3788954 + 711 WP_007250189.1 rRNA pseudouridine synthase -
PMA4326_RS17365 3789031..3789492 + 462 WP_007250188.1 DUF1456 family protein -
PMA4326_RS17370 3789506..3790213 + 708 WP_007250187.1 tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(2-31)

Antitoxin

HigA2-like, helix-turn-helix domain

(11-90)


Sequences

Toxin        


Download         Length: 43 a.a.        Molecular weight: 4795.60 Da        Isoelectric Point: 10.8288

>T145631 WP_122320264.1 NZ_CP047260:c3785968-3785840 [Pseudomonas syringae pv. maculicola str. ES4326]
MVYVLHCFQKKSTSGIKTAKHDIELIKSRLKAAQAHAESNRR

Download         Length: 129 bp

>T145631 NZ_CP062412:c183563-183468 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11639.62 Da        Isoelectric Point: 10.2027

>AT145631 WP_004397562.1 NZ_CP047260:c3785843-3785523 [Pseudomonas syringae pv. maculicola str. ES4326]
MIDIEEGSGNVYADLGRADANEMSIKAQLASKIGTIIKARHLTQLQAAEILAMPQPKVSEMLRGKFRGISEAKMMDCLSR
LGRDVQIVVKAAPRSRREGRVEVVFA

Download         Length: 321 bp

>AT145631 NZ_CP062412:183383-183440 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0K8LSV9

References