145629

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1935457..1936063 Replicon chromosome
Accession NZ_CP047248
Organism Streptococcus suis strain LSM178

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag GRI05_RS09560 Protein ID WP_012775364.1
Coordinates 1935457..1935786 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag GRI05_RS09565 Protein ID WP_012028535.1
Coordinates 1935776..1936063 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRI05_RS09530 1930869..1932599 - 1731 WP_012775361.1 membrane protein -
GRI05_RS09535 1932964..1933872 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
GRI05_RS09540 1933856..1934386 - 531 WP_009910909.1 DUF1697 domain-containing protein -
GRI05_RS09545 1934400..1934657 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
GRI05_RS09550 1934659..1934919 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GRI05_RS09555 1934995..1935450 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
GRI05_RS09560 1935457..1935786 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GRI05_RS09565 1935776..1936063 - 288 WP_012028535.1 hypothetical protein Antitoxin
GRI05_RS09570 1936161..1936529 - 369 WP_012775453.1 hypothetical protein -
GRI05_RS09575 1936522..1937091 - 570 WP_012775366.1 ribonuclease M5 -
GRI05_RS09580 1937075..1937857 - 783 WP_012028536.1 TatD family hydrolase -
GRI05_RS09585 1937964..1938101 - 138 WP_002939016.1 50S ribosomal protein L34 -
GRI05_RS09590 1938269..1939264 - 996 WP_012775367.1 protein jag -
GRI05_RS09595 1939284..1940096 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
GRI05_RS09600 1940080..1940439 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T145629 WP_012775364.1 NZ_CP047248:c1935786-1935457 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T145629 NZ_CP062412:18899-19075 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT145629 WP_012028535.1 NZ_CP047248:c1936063-1935776 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT145629 NZ_CP062412:c19237-19063 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References