145626

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1274621..1275107 Replicon chromosome
Accession NZ_CP047248
Organism Streptococcus suis strain LSM178

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag GRI05_RS06230 Protein ID WP_011922754.1
Coordinates 1274621..1274890 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag GRI05_RS06235 Protein ID WP_002938604.1
Coordinates 1274880..1275107 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRI05_RS06205 1269674..1270591 - 918 WP_002937252.1 DNA-binding protein WhiA -
GRI05_RS06210 1270588..1271562 - 975 WP_002937257.1 YvcK family protein -
GRI05_RS06215 1271559..1272446 - 888 WP_011922160.1 RNase adapter RapZ -
GRI05_RS06220 1272468..1272845 - 378 WP_043029003.1 RidA family protein -
GRI05_RS06225 1272896..1274215 - 1320 WP_012775027.1 MATE family efflux transporter -
GRI05_RS06230 1274621..1274890 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GRI05_RS06235 1274880..1275107 - 228 WP_002938604.1 hypothetical protein Antitoxin
GRI05_RS06240 1275379..1276725 - 1347 WP_011922752.1 asparagine--tRNA ligase -
GRI05_RS06245 1276740..1277921 - 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
GRI05_RS06250 1277918..1278415 - 498 WP_011922751.1 DUF5590 domain-containing protein -
GRI05_RS06260 1279615..1280064 + 450 WP_009909619.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T145626 WP_011922754.1 NZ_CP047248:c1274890-1274621 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T145626 NZ_CP062411:2670278-2670487 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT145626 WP_002938604.1 NZ_CP047248:c1275107-1274880 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT145626 NZ_CP062411:2669973-2670266 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References