145625

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1023675..1024167 Replicon chromosome
Accession NZ_CP047248
Organism Streptococcus suis strain LSM178

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag GRI05_RS05060 Protein ID WP_011922404.1
Coordinates 1023910..1024167 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag GRI05_RS05055 Protein ID WP_012775104.1
Coordinates 1023675..1023926 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRI05_RS05035 1019242..1019988 + 747 WP_011922411.1 ABC transporter permease -
GRI05_RS05040 1019990..1020724 + 735 WP_011922410.1 ABC transporter permease -
GRI05_RS05045 1020860..1021612 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
GRI05_RS05050 1021613..1023583 + 1971 WP_012775105.1 FtsX-like permease family protein -
GRI05_RS05055 1023675..1023926 + 252 WP_012775104.1 hypothetical protein Antitoxin
GRI05_RS05060 1023910..1024167 + 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GRI05_RS05065 1024206..1024871 + 666 WP_012775103.1 response regulator transcription factor -
GRI05_RS05070 1024868..1025809 + 942 WP_012775102.1 sensor histidine kinase -
GRI05_RS05075 1025885..1027393 + 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
GRI05_RS05080 1027463..1028533 - 1071 WP_043029021.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T145625 WP_011922404.1 NZ_CP047248:1023910-1024167 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T145625 NZ_CP062411:2612883-2612987 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT145625 WP_012775104.1 NZ_CP047248:1023675-1023926 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT145625 NZ_CP062411:c2613145-2612982 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References