Detailed information of TA system TA145623

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Xre-MNT/HTH_26(antitoxin)
• Location: 960822..961930
• Replicon: chromosome
• Accession: NZ_CP047248
• Organism: Streptococcus suis strain LSM178

Toxin (Protein)

• Gene name: MNTss
• Uniprot ID: R3JIN1
• Locus tag: GRI05_RS04710
• Protein ID: WP_000233000.1
• Coordinates: 960822..961691 (-)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: Xress
• Uniprot ID: -
• Locus tag: GRI05_RS04715
• Protein ID: WP_000205227.1
• Coordinates: 961706..961930 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GRI05_RS04690	957093..958412	-	1320	WP_002338419.1	IS1380-like element ISSsu5 family transposase	-
GRI05_RS04695	958640..959167	-	528	WP_002294507.1	adenine phosphoribosyltransferase	-
GRI05_RS04700	959211..960074	-	864	WP_002294505.1	aminoglycoside nucleotidyltransferase ANT(6)-Ia	-
GRI05_RS04705	960107..960841	-	735	WP_000662263.1	class I SAM-dependent methyltransferase	-
GRI05_RS04710	960822..961691	-	870	WP_000233000.1	nucleotidyltransferase domain-containing protein	Toxin
GRI05_RS04715	961706..961930	-	225	WP_000205227.1	helix-turn-helix transcriptional regulator	Antitoxin
GRI05_RS04720	962073..963635	-	1563	WP_000136908.1	recombinase family protein	-
GRI05_RS04725	963637..964053	-	417	WP_000323438.1	recombinase	-
GRI05_RS04730	964054..964350	-	297	WP_002360685.1	hypothetical protein	-
GRI05_RS04735	964878..965534	+	657	Protein_888	lantibiotic-modifying protein	-
GRI05_RS04740	965518..966846	+	1329	Protein_889	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	ant(6)-Ia / erm(B) / tet(M)	-	921107..1022339	101232
	-	flank	IS/Tn	ant(6)-Ia	-	957093..960074	2981

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polymerase, nucleotidyl transferase domain (12-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-57)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 32926.57 Da
• Isoelectric Point: 4.8781

>T145623 WP_000233000.1 NZ_CP047248:c961691-960822 [Streptococcus suis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Nucleotide

• Length: 870 bp

>T145623 NZ_CP062411:2327788-2327895 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8365.68 Da
• Isoelectric Point: 4.5510

>AT145623 WP_000205227.1 NZ_CP047248:c961930-961706 [Streptococcus suis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Nucleotide

• Length: 225 bp

>AT145623 NZ_CP062411:c2327972-2327912 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: R3JIN1