Detailed information of TA system TA145622

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 940129..941561
• Replicon: chromosome
• Accession: NZ_CP047248
• Organism: Streptococcus suis strain LSM178

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: GRI05_RS04640
• Protein ID: WP_043029016.1
• Coordinates: 940129..940974 (-)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: A0A0Z8YIZ2
• Locus tag: GRI05_RS04645
• Protein ID: WP_011922457.1
• Coordinates: 940971..941561 (-)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GRI05_RS04635	937265..940066	+	2802	WP_011922459.1	CHAP domain-containing protein	-
GRI05_RS04640	940129..940974	-	846	WP_043029016.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
GRI05_RS04645	940971..941561	-	591	WP_011922457.1	transcriptional regulator	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	ant(6)-Ia / erm(B) / tet(M)	-	921107..1022339	101232

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32504.26 Da
• Isoelectric Point: 5.2111

>T145622 WP_043029016.1 NZ_CP047248:c940974-940129 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETVLDFEKIIELLERFKSDP
IQNQQWQNYSKKYSYTKGISLADVLDEMIRLIAVLISINFD

Nucleotide

• Length: 846 bp

>T145622 NZ_CP062411:2296504-2296770 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23151.74 Da
• Isoelectric Point: 7.8272

>AT145622 WP_011922457.1 NZ_CP047248:c941561-940971 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKENSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQLYGNYPKKNLTKLYEYATKMSTLAKVKQTLEVLV

Nucleotide

• Length: 591 bp

>AT145622 NZ_CP062411:2296247-2296504 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0Z8YIZ2