Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 4503889..4504844 Replicon chromosome
Accession NZ_CP047235
Organism Gordonia sp. JH63

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag GR168_RS19945 Protein ID WP_078113767.1
Coordinates 4503889..4504464 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag GR168_RS19950 Protein ID WP_078113766.1
Coordinates 4504461..4504844 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GR168_RS19920 4500143..4501150 + 1008 WP_159371518.1 LacI family transcriptional regulator -
GR168_RS19925 4501154..4501471 - 318 WP_159371519.1 DUF2470 domain-containing protein -
GR168_RS19930 4501464..4502195 - 732 WP_159371520.1 tyrosine-protein phosphatase -
GR168_RS19935 4502288..4502920 + 633 WP_159371521.1 flavin reductase family protein -
GR168_RS19940 4502945..4503892 - 948 WP_159371522.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
GR168_RS19945 4503889..4504464 - 576 WP_078113767.1 zeta toxin family protein Toxin
GR168_RS19950 4504461..4504844 - 384 WP_078113766.1 hypothetical protein Antitoxin
GR168_RS19955 4504968..4505516 - 549 WP_078113765.1 peptide-methionine (S)-S-oxide reductase MsrA -
GR168_RS19960 4505513..4505998 - 486 WP_159371523.1 peptide-methionine (R)-S-oxide reductase MsrB -
GR168_RS19965 4506155..4507309 - 1155 WP_159371981.1 acyl-CoA dehydrogenase family protein -
GR168_RS19970 4507326..4508414 - 1089 WP_078113762.1 VOC family protein -
GR168_RS19975 4508661..4509554 + 894 WP_078113761.1 acetaldehyde dehydrogenase (acetylating) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(2-141)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-71)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21174.28 Da        Isoelectric Point: 9.8994

>T145614 WP_078113767.1 NZ_CP047235:c4504464-4503889 [Gordonia sp. JH63]
VTPRLDLVVGCNGAGKSTLVERHLQPLLHVPFVNADLIARQRWPDSAEAHSYDAARLAAATRDTLIERGTSFIAETVFSH
PSKLELIERAHTAGYRVALHVVMIPEALAVHRVRLRVDSGGHAVPEVKIRERFRRLWPLVRTAIARSDLATVYANEQPTT
RIVARYVDGLVAGVPDWPDWTPGALTDTKAR

Download         Length: 576 bp

>T145614 NZ_CP062410:2364441-2364707 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 13659.06 Da        Isoelectric Point: 5.2363

>AT145614 WP_078113766.1 NZ_CP047235:c4504844-4504461 [Gordonia sp. JH63]
MSTGTDKVTRLSAALVTDAAREGAREQRSARQQLEHWARLGRSVSQRTTASRQRVEAALAGDLSGEVLTAEEAVVYDAEV
DAHLEARLATDDHVVRRASAGLSSVVVDDAGRLVEHRPDGTSVILEQ

Download         Length: 384 bp

>AT145614 NZ_CP062410:2364190-2364441 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References