Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 1250147..1250820 Replicon chromosome
Accession NZ_CP047235
Organism Gordonia sp. JH63

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GR168_RS05645 Protein ID WP_137810536.1
Coordinates 1250416..1250820 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GR168_RS05640 Protein ID WP_159370254.1
Coordinates 1250147..1250419 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GR168_RS05625 1245691..1246673 + 983 Protein_1104 LLM class F420-dependent oxidoreductase -
GR168_RS05630 1247068..1248234 - 1167 WP_159370252.1 pyridoxal phosphate-dependent aminotransferase -
GR168_RS05635 1248332..1250005 + 1674 WP_159370253.1 serine/threonine protein kinase -
GR168_RS05640 1250147..1250419 + 273 WP_159370254.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GR168_RS05645 1250416..1250820 + 405 WP_137810536.1 type II toxin-antitoxin system VapC family toxin Toxin
GR168_RS05650 1250822..1252498 - 1677 WP_065631752.1 DEAD/DEAH box helicase -
GR168_RS05655 1252565..1253494 - 930 WP_159370255.1 DUF2236 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-46)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14167.42 Da        Isoelectric Point: 4.6533

>T145613 WP_137810536.1 NZ_CP047235:1250416-1250820 [Gordonia sp. JH63]
MIYLDTSAMVKLVVREAETAPLIEWFALRPGVPTVTSALGRVELMRTALRDGSPGLHERARDLLDALDVIPLSAAVIDIA
ESIGPSSLRSLDALHLASATVIRAEMTAFVAYDQRLTAGASALGYPVVAPGAEL

Download         Length: 405 bp

>T145613 NZ_CP062410:2339165-2339272 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9795.21 Da        Isoelectric Point: 10.3630

>AT145613 WP_159370254.1 NZ_CP047235:1250147-1250419 [Gordonia sp. JH63]
MRTIGIRELRQHASQYLAQVEAGEELAITNRGRTVARLVPVSAGERSREALIEAGILVPARSAGGITGLHPETLPTRALT
KVLDQVREDR

Download         Length: 273 bp

>AT145613 NZ_CP062410:c2339349-2339289 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References