Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 793663..794333 Replicon chromosome
Accession NZ_CP047232
Organism Brucella sp. BO3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GRI33_RS03770 Protein ID WP_008504608.1
Coordinates 793929..794333 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D1CXH4
Locus tag GRI33_RS03765 Protein ID WP_008504606.1
Coordinates 793663..793932 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRI33_RS03745 790681..790878 + 198 WP_002963959.1 DUF3008 family protein -
GRI33_RS03750 790923..791336 - 414 WP_069715225.1 hypothetical protein -
GRI33_RS03755 791608..792579 - 972 WP_069715224.1 extensin family protein -
GRI33_RS03760 792914..793531 + 618 WP_002967582.1 30S ribosomal protein S4 -
GRI33_RS03765 793663..793932 + 270 WP_008504606.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GRI33_RS03770 793929..794333 + 405 WP_008504608.1 type II toxin-antitoxin system VapC family toxin Toxin
GRI33_RS03775 794628..795509 + 882 WP_069715223.1 tRNA 2-thiocytidine(32) synthetase TtcA -
GRI33_RS03780 795496..796323 + 828 WP_069715222.1 inositol monophosphatase family protein -
GRI33_RS03785 796538..797803 - 1266 WP_002963966.1 multidrug effflux MFS transporter -
GRI33_RS03790 798074..798406 - 333 WP_009364410.1 Grx4 family monothiol glutaredoxin -
GRI33_RS03795 798591..798824 - 234 WP_002963968.1 BolA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-118)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14365.66 Da        Isoelectric Point: 5.6366

>T145610 WP_008504608.1 NZ_CP047232:793929-794333 [Brucella sp. BO3]
MSKLYMLDTNIVSDLARNPHGPVAKHIARVGADAICVSIITACELRYGCAKKGSPRLLAQIEAILDSIEILPLDVPADTE
YGGIRAELEADGKPIGPNDFLIAAHAYALGAVLVTANVGEFTRIRKLAVENWLN

Download         Length: 405 bp

>T145610 NZ_CP062410:c175062-174967 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10046.62 Da        Isoelectric Point: 7.2059

>AT145610 WP_008504606.1 NZ_CP047232:793663-793932 [Brucella sp. BO3]
MAHARRIEPTPAREAKLFRNNKSQAVRIPADFEFPGNRVLIHREGDKLIIEPVRRKNLLEVLAGLKPLGPEDAFPDIDDT
ALPLKDVDL

Download         Length: 270 bp

>AT145610 NZ_CP062410:174882-174939 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7L7MKG1

References