Detailed information of TA system TA145581

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 2069924..2070495
• Replicon: chromosome
• Accession: NZ_CP047226
• Organism: Moraxella osloensis strain YV1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: GSF12_RS09470
• Protein ID: WP_159375751.1
• Coordinates: 2069924..2070262 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: GSF12_RS09475
• Protein ID: WP_101965173.1
• Coordinates: 2070253..2070495 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSF12_RS09445	2065267..2066805	+	1539	WP_159375268.1	VENN motif pre-toxin domain-containing protein	-
GSF12_RS09450	2067202..2068266	-	1065	WP_159375269.1	transposase	-
GSF12_RS09455	2068534..2068848	-	315	WP_201450547.1	helix-turn-helix domain-containing protein	-
GSF12_RS09460	2068854..2069171	-	318	WP_159375270.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GSF12_RS09465	2069276..2069881	-	606	WP_159375271.1	recombinase family protein	-
GSF12_RS09470	2069924..2070262	-	339	WP_159375751.1	endoribonuclease MazF	Toxin
GSF12_RS09475	2070253..2070495	-	243	WP_101965173.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GSF12_RS09480	2070712..2070837	+	126	WP_159375272.1	hypothetical protein	-
GSF12_RS09485	2070847..2074218	-	3372	WP_159375273.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-110)

Antitoxin

• Antitoxin PemI-like (1-79)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12225.20 Da
• Isoelectric Point: 7.8793

>T145581 WP_159375751.1 NZ_CP047226:c2070262-2069924 [Moraxella osloensis]
IAMSYIPEVGDIIWLEFDPQAGHEQAGHRPAVVLTPKAYNQATGLLICCPLTTKIKGYPFEVTIEGTPQNVALSDQVKSL
DWKARKAKHKGSVSQAELETIKQKIGLLLAIS

Nucleotide

• Length: 339 bp

>T145581 NZ_CP062407:2207087-2207296 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8821.16 Da
• Isoelectric Point: 4.5338

>AT145581 WP_101965173.1 NZ_CP047226:c2070495-2070253 [Moraxella osloensis]
MQVTMRKWGNSIGVRIPAGILTELNLSAEKKVDVRAEAGRIIIEPIIDSQETLEQLLGQITPDNVHSEIDFGQPVGKELL

Nucleotide

• Length: 243 bp

>AT145581 NZ_CP062407:2206782-2207075 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA