145579

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 21569..22266 Replicon plasmid unnamed2
Accession NZ_CP047221
Organism Sphingobium yanoikuyae strain YC-JY1

Toxin (Protein)


Gene name tad Uniprot ID T0J3S2
Locus tag GS397_RS27165 Protein ID WP_013041565.1
Coordinates 21569..21943 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID T0G937
Locus tag GS397_RS27170 Protein ID WP_006964370.1
Coordinates 21940..22266 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS397_RS27135 16947..17219 + 273 Protein_15 Flp pilus assembly complex ATPase component TadA -
GS397_RS27140 17262..18026 + 765 WP_001389365.1 IS6-like element IS6100 family transposase -
GS397_RS27145 18128..19399 - 1272 WP_159368309.1 cytochrome P450 -
GS397_RS27150 19474..19791 - 318 WP_119594020.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -
GS397_RS27155 20138..20902 - 765 WP_001389365.1 IS6-like element IS6100 family transposase -
GS397_RS27160 20966..21313 + 348 Protein_20 IS6-like element IS6100 family transposase -
GS397_RS27165 21569..21943 + 375 WP_013041565.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GS397_RS27170 21940..22266 + 327 WP_006964370.1 helix-turn-helix domain-containing protein Antitoxin
GS397_RS27175 22266..22508 + 243 WP_006964372.1 hypothetical protein -
GS397_RS27180 22501..22800 + 300 WP_006964373.1 hypothetical protein -
GS397_RS27185 22821..23933 - 1113 WP_030092736.1 muramidase -
GS397_RS27190 23936..25651 - 1716 WP_030092735.1 P-type conjugative transfer protein TrbL -
GS397_RS27195 25662..25904 - 243 WP_019053956.1 EexN family lipoprotein -
GS397_RS27200 25914..26669 - 756 WP_022675885.1 P-type conjugative transfer protein TrbJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..66704 66704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(15-94)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13960.67 Da        Isoelectric Point: 9.4885

>T145579 WP_013041565.1 NZ_CP047221:21569-21943 [Sphingobium yanoikuyae]
MDTERPVRWVASSKRDFREFPDDVQDVMGYALHLAQQGGQHASTKPLKGFGGAGVVEIIDDHQGDTFRTVYTVKFAEAVY
VLHAFQKKSKQGKATPQADMDLIRTRLKSAEEHHRQHQTPRGTA

Download         Length: 375 bp

>T145579 NZ_CP062407:1882377-1882643 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11792.57 Da        Isoelectric Point: 7.1681

>AT145579 WP_006964370.1 NZ_CP047221:21940-22266 [Sphingobium yanoikuyae]
MSAQDEIIEEGSGNVFADLGFADPDTHLLKAQLVTRVAEAMQERKLTQIAAAKVTGSTQPELSRILRGQFRSVSVERLLA
MLTRLGCKVDIVVRPQGRTTESAVIHFA

Download         Length: 327 bp

>AT145579 NZ_CP062407:1882126-1882377 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACGCTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J7XHG4

Antitoxin

Source ID Structure
AlphaFold DB A0A0J8A803

References