Detailed information of TA system TA145578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 9139..9698
• Replicon: plasmid unnamed3
• Accession: NZ_CP047220
• Organism: Sphingobium yanoikuyae strain YC-JY1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GS397_RS26780
• Protein ID: WP_159368258.1
• Coordinates: 9139..9432 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GS397_RS26785
• Protein ID: WP_159368259.1
• Coordinates: 9420..9698 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GS397_RS26725	4677..4934	-	258	Protein_4	hypothetical protein	-
GS397_RS26730	4977..5159	-	183	Protein_5	cytoplasmic protein	-
GS397_RS26735	5182..5475	-	294	WP_159368253.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GS397_RS26740	5468..5746	-	279	WP_159368254.1	type II toxin-antitoxin system ParD family antitoxin	-
GS397_RS26745	5879..6007	+	129	WP_159368255.1	hypothetical protein	-
GS397_RS26750	5994..6224	+	231	WP_159368256.1	BrnA antitoxin family protein	-
GS397_RS26755	6256..6583	+	328	Protein_10	hypothetical protein	-
GS397_RS26760	6626..7018	-	393	Protein_11	IS66 family insertion sequence element accessory protein TnpB	-
GS397_RS26765	6920..8293	+	1374	WP_159368257.1	hypothetical protein	-
GS397_RS26770	8730..9011	+	282	WP_082635049.1	WGR domain-containing protein	-
GS397_RS26775	9026..9121	-	96	Protein_14	histidine phosphatase family protein	-
GS397_RS26780	9139..9432	-	294	WP_159368258.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GS397_RS26785	9420..9698	-	279	WP_159368259.1	CopG family ribbon-helix-helix protein	Antitoxin
GS397_RS26790	10078..10638	+	561	WP_159368303.1	recombinase family protein	-
GS397_RS26795	10653..11990	+	1338	WP_159368260.1	phosphoglucosamine mutase	-
GS397_RS26800	12021..12329	-	309	WP_159368261.1	hypothetical protein	-
GS397_RS26805	12326..13582	-	1257	WP_159368262.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..65025	65025
	-	flank	IS/Tn	-	-	10078..10638	560

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11011.58 Da
• Isoelectric Point: 9.5295

>T145578 WP_159368258.1 NZ_CP047220:c9432-9139 [Sphingobium yanoikuyae]
VPRLIWTAEALADVGRLHRWLKTKDADAVRRAVAAIRGRVRILAATPHIGRPTEDMESEYREKLIDFGNSGYVVLYHFDG
ETVALLAVRHQREAGYQ

Nucleotide

• Length: 294 bp

>T145578 NZ_CP062407:1857163-1857270 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10636.01 Da
• Isoelectric Point: 6.9793

>AT145578 WP_159368259.1 NZ_CP047220:c9698-9420 [Sphingobium yanoikuyae]
MATATSIKLDHALKGRVQHLANARRRSSHWIMREAIAQYVEREEKREAFKQDAIRAWENYQQTGLHVTLEEADVWLAKLE
AGEDAEPPKCHV

Nucleotide

• Length: 279 bp

>AT145578 NZ_CP062407:c1857347-1857287 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA