Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4990144..4991687 Replicon chromosome
Accession NZ_CP047218
Organism Sphingobium yanoikuyae strain YC-JY1

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag GS397_RS23685 Protein ID WP_159367815.1
Coordinates 4990362..4991687 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag GS397_RS23680 Protein ID WP_159367814.1
Coordinates 4990144..4990359 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS397_RS23665 4986334..4987527 + 1194 WP_159367811.1 hypothetical protein -
GS397_RS23670 4987638..4989365 + 1728 WP_159367812.1 AAA family ATPase -
GS397_RS23675 4989362..4989943 + 582 WP_159367813.1 radical SAM protein -
GS397_RS23680 4990144..4990359 + 216 WP_159367814.1 helix-turn-helix domain-containing protein Antitoxin
GS397_RS23685 4990362..4991687 + 1326 WP_159367815.1 type II toxin-antitoxin system HipA family toxin Toxin
GS397_RS23690 4991820..4992290 + 471 WP_159367816.1 hypothetical protein -
GS397_RS23695 4992731..4994005 + 1275 WP_159368126.1 tyrosine-type recombinase/integrase -
GS397_RS23700 4994062..4994259 - 198 WP_159367817.1 helix-turn-helix domain-containing protein -
GS397_RS23705 4994561..4995574 - 1014 WP_159367818.1 RNA 3'-terminal phosphate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4965496..5005742 40246


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-63)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 47376.90 Da        Isoelectric Point: 4.9828

>T145575 WP_159367815.1 NZ_CP047218:4990362-4991687 [Sphingobium yanoikuyae]
VDLPVHFEDRLVATIGADTQATRLAYDETWLSSPDSFPVSLAMPIRPEPYEGEQVLPWLMNLLPEGEPLRAMTRVLGAAP
EDALGLIAQTGNDLAGALCIAPQQPRGEPGYRSISDADALARIIEELPARPFLVGEDGVSMSLAGAQEKLPVAILDGQIA
IPINGAPSTHILKPDNPRLPGSVQNEALCMVLARRIGLNVAPVTTGVAGERSYLLVERYDRTGTGNNVRRLHQEDFCQAL
GRPPAAKYEFNGTGTRGPSVADMFALVRQHMTARDITRLLDAVIFNVAIGNVDSHAKNYSILLDPGAPQLAPLYDLMSGL
AWANITQNHAQAIGAQRRGRHIYGRHWRRMAEAAGLAPRGTVQRVEQVTTRLLRELPATIDEVAAMPAGSTMLEVFAKEI
EERATEVKAHAGQEGVPDVVEIATNEVPTIGASAYSVDGGA

Download         Length: 1326 bp

>T145575 NZ_CP062407:687978-688166 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7163.31 Da        Isoelectric Point: 10.7685

>AT145575 WP_159367814.1 NZ_CP047218:4990144-4990359 [Sphingobium yanoikuyae]
MIDNATQFGAAVASARKALGLTQRELALAINSGERFIVDLEAGKPTAQLGKALAAAKAVGLRLTAAGITQA

Download         Length: 216 bp

>AT145575 NZ_CP062407:687689-687949 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References