Detailed information of TA system TA145573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 2861085..2861782
• Replicon: chromosome
• Accession: NZ_CP047218
• Organism: Sphingobium yanoikuyae strain YC-JY1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GS397_RS13540
• Protein ID: WP_159366766.1
• Coordinates: 2861351..2861782 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A177JPX4
• Locus tag: GS397_RS13535
• Protein ID: WP_010336339.1
• Coordinates: 2861085..2861354 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GS397_RS13510	2856867..2857283	+	417	WP_159366762.1	hypothetical protein	-
GS397_RS13515	2857409..2859163	-	1755	WP_159366763.1	ParB/RepB/Spo0J family partition protein	-
GS397_RS13520	2859606..2860145	-	540	WP_159366764.1	AAA family ATPase	-
GS397_RS13525	2860597..2860836	+	240	WP_010336341.1	AlpA family phage regulatory protein	-
GS397_RS13530	2860823..2861035	+	213	WP_159366765.1	hypothetical protein	-
GS397_RS13535	2861085..2861354	+	270	WP_010336339.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GS397_RS13540	2861351..2861782	+	432	WP_159366766.1	type II toxin-antitoxin system VapC family toxin	Toxin
GS397_RS13545	2861782..2863422	+	1641	WP_159366767.1	recombinase family protein	-
GS397_RS13550	2863475..2864053	-	579	WP_159366768.1	XRE family transcriptional regulator	-
GS397_RS13555	2864069..2864971	+	903	WP_010336335.1	DMT family transporter	-
GS397_RS13560	2864996..2865754	-	759	WP_159366769.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2848139..2863422	15283

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-62)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15846.01 Da
• Isoelectric Point: 4.6456

>T145573 WP_159366766.1 NZ_CP047218:2861351-2861782 [Sphingobium yanoikuyae]
MSFLLDTNIISEGAKPRPDPGVMDWLASVDEEELFLSVVSLAELRHGIERMDKGARQSGLDIWLTEQLAPRFEARLLSID
SVTADLWGRIVNRAQGAGRPMGAMDAFIAAHAQQHELTLVTRNISDFEATGIRLFNPWTEGKA

Nucleotide

• Length: 432 bp

>T145573 NZ_CP062406:2622613-2622822 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10101.49 Da
• Isoelectric Point: 8.8908

>AT145573 WP_010336339.1 NZ_CP047218:2861085-2861354 [Sphingobium yanoikuyae]
MVVETHPDSWTVAQAKARLSEVIEKARREPQAITRHGKSAVVVVDAELWERVQRRQHRGSFADFLLTSPLRGSGLEVDRL
KDGVREIDL

Nucleotide

• Length: 270 bp

>AT145573 NZ_CP062406:2622308-2622601 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A177JPX4