Detailed information of TA system TA145572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1660902..1661560
• Replicon: chromosome
• Accession: NZ_CP047218
• Organism: Sphingobium yanoikuyae strain YC-JY1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A084EIW7
• Locus tag: GS397_RS07965
• Protein ID: WP_037520637.1
• Coordinates: 1660902..1661339 (-)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GS397_RS07970
• Protein ID: WP_196221871.1
• Coordinates: 1661336..1661560 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GS397_RS07940	1656379..1656765	+	387	WP_037520639.1	hypothetical protein	-
GS397_RS07945	1656762..1657154	+	393	WP_159366128.1	hypothetical protein	-
GS397_RS07950	1657208..1658014	-	807	WP_159366129.1	IS21-like element helper ATPase IstB	-
GS397_RS07955	1658004..1659527	-	1524	WP_159366130.1	IS21 family transposase	-
GS397_RS07960	1659982..1660902	-	921	WP_037520638.1	HEPN domain-containing protein	-
GS397_RS07965	1660902..1661339	-	438	WP_037520637.1	PIN domain-containing protein	Toxin
GS397_RS07970	1661336..1661560	-	225	WP_196221871.1	CopG family transcriptional regulator	Antitoxin
GS397_RS07975	1661592..1661951	-	360	WP_159366131.1	MarR family winged helix-turn-helix transcriptional regulator	-
GS397_RS07980	1662056..1662955	-	900	WP_037520632.1	phytanoyl-CoA dioxygenase family protein	-
GS397_RS07985	1662967..1663581	-	615	WP_037520631.1	autoinducer synthase	-
GS397_RS07990	1663720..1664478	-	759	WP_037520629.1	LuxR family transcriptional regulator	-
GS397_RS07995	1665075..1665350	-	276	WP_037520628.1	HU family DNA-binding protein	-
GS397_RS08000	1665427..1665693	-	267	WP_037520626.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1554709..1691357	136648

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15628.87 Da
• Isoelectric Point: 6.7650

>T145572 WP_037520637.1 NZ_CP047218:c1661339-1660902 [Sphingobium yanoikuyae]
MTYLLDVNVLVALIDPNHVGHEAAHHWFETEGGKAWATCPITENGVIRIVGNVRYPSTPGSPAEVASIMAQMCKLPGHRF
WAEDISLLSAEHVDASHILTSAQVTDTYLLALAVANKGKLATFDRRLTPKGVTGGKDAIHLIGNH

Nucleotide

• Length: 438 bp

>T145572 NZ_CP062406:2565316-2565420 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7908.05 Da
• Isoelectric Point: 7.3199

>AT145572 WP_196221871.1 NZ_CP047218:c1661560-1661336 [Sphingobium yanoikuyae]
MRTTLVIDDDVMAAARAIADHQHSSIGRVLSDLARKALHAPEAARTRNGISLLPTKPGVVVTQDIVNALRDEAP

Nucleotide

• Length: 225 bp

>AT145572 NZ_CP062406:c2565578-2565415 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A084EIW7