Detailed information of TA system TA145571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1308821..1309494
• Replicon: chromosome
• Accession: NZ_CP047218
• Organism: Sphingobium yanoikuyae strain YC-JY1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GS397_RS06265
• Protein ID: WP_159365971.1
• Coordinates: 1308821..1309243 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GS397_RS06270
• Protein ID: WP_048576566.1
• Coordinates: 1309240..1309494 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GS397_RS06215	1304039..1304371	+	333	WP_159365964.1	AraC family transcriptional regulator	-
GS397_RS27840	1304613..1304825	+	213	WP_201450313.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GS397_RS06225	1304886..1305209	+	324	WP_159365965.1	XRE family transcriptional regulator	-
GS397_RS06230	1305249..1305599	+	351	WP_159365966.1	hypothetical protein	-
GS397_RS06235	1305652..1306104	+	453	WP_159365967.1	MucR family transcriptional regulator	-
GS397_RS06240	1306158..1306319	-	162	WP_201450266.1	DUF736 family protein	-
GS397_RS06245	1306739..1307065	+	327	WP_159365968.1	nuclear transport factor 2 family protein	-
GS397_RS06250	1307174..1307410	-	237	WP_201450314.1	DUF736 family protein	-
GS397_RS06255	1307407..1307778	-	372	WP_159365969.1	hypothetical protein	-
GS397_RS06260	1307898..1308824	-	927	WP_159365970.1	HEPN domain-containing protein	-
GS397_RS06265	1308821..1309243	-	423	WP_159365971.1	type II toxin-antitoxin system VapC family toxin	Toxin
GS397_RS06270	1309240..1309494	-	255	WP_048576566.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
GS397_RS06275	1309997..1310857	-	861	WP_159365972.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
GS397_RS06280	1310854..1311534	-	681	WP_159365973.1	hypothetical protein	-
GS397_RS06285	1311897..1312457	-	561	WP_159365974.1	RES family NAD+ phosphorylase	-
GS397_RS06290	1312464..1313099	-	636	WP_159365975.1	hypothetical protein	-
GS397_RS06295	1313216..1313692	+	477	WP_159365976.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1278872..1354498	75626

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-125)

Antitoxin

• Antitoxin VapB-like (5-83)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15381.56 Da
• Isoelectric Point: 5.2066

>T145571 WP_159365971.1 NZ_CP047218:c1309243-1308821 [Sphingobium yanoikuyae]
VIVDTSALIAILYGEQEAPIFAEIIHKADVCRLSVASYVELTIVVEKQLGPEGTRHAENFVRRAGIQIEPVTLEQGLIAR
QAFFDFGKGRHRAALNYGDCFPYALAKAVDEPLLFKGNDFSQTDVESALPRANPPVTTRP

Nucleotide

• Length: 423 bp

>T145571 NZ_CP062406:2299611-2299877 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9314.61 Da
• Isoelectric Point: 7.2036

>AT145571 WP_048576566.1 NZ_CP047218:c1309494-1309240 [Sphingobium yanoikuyae]
MSGTLNIKDPEAHRLALAIAQETGEPMTRVVIEALRDRLSRIERQRERASVSELLTIAGRAAKLVTKPYSTHGDELYDSD
GLPK

Nucleotide

• Length: 255 bp

>AT145571 NZ_CP062406:2299360-2299611 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA