Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 1055980..1056618 Replicon chromosome
Accession NZ_CP047218
Organism Sphingobium yanoikuyae strain YC-JY1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GS397_RS05140 Protein ID WP_048938827.1
Coordinates 1056217..1056618 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0J9FLQ9
Locus tag GS397_RS05135 Protein ID WP_010338822.1
Coordinates 1055980..1056213 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS397_RS05105 1051767..1052192 + 426 WP_159365878.1 PRTRC system protein E -
GS397_RS05110 1052247..1052453 + 207 WP_159365879.1 hypothetical protein -
GS397_RS05115 1052796..1053653 + 858 Protein_1009 hypothetical protein -
GS397_RS05120 1053665..1054495 + 831 WP_159365880.1 PRTRC system protein B -
GS397_RS05125 1054492..1055151 + 660 WP_159365881.1 PRTRC system protein A -
GS397_RS05130 1055141..1055944 + 804 WP_159365882.1 PRTRC system ThiF family protein -
GS397_RS05135 1055980..1056213 + 234 WP_010338822.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GS397_RS05140 1056217..1056618 + 402 WP_048938827.1 type II toxin-antitoxin system VapC family toxin Toxin
GS397_RS05145 1056810..1058180 + 1371 WP_159365883.1 hypothetical protein -
GS397_RS05150 1058711..1059796 + 1086 WP_159365884.1 DUF4297 domain-containing protein -
GS397_RS05155 1059854..1061542 + 1689 WP_159365885.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1015165..1132319 117154


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(10-55)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14437.62 Da        Isoelectric Point: 4.7363

>T145570 WP_048938827.1 NZ_CP047218:1056217-1056618 [Sphingobium yanoikuyae]
MFLLDTNILSDLIRQPDGMVAHAIADVGEDAVATSIIVAGELRYGAEKRGSPRLKSKIEDLLSLIAVLPLKDDADACYGR
LRADLERRGTPIGANDMLIAAHALAIGATLVTDNIREFERVDGLQLVNWLRTT

Download         Length: 402 bp

>T145570 NZ_CP062406:2274335-2274442 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8809.19 Da        Isoelectric Point: 4.8723

>AT145570 WP_010338822.1 NZ_CP047218:1055980-1056213 [Sphingobium yanoikuyae]
MNLERHVKLFKNGRSQAVRIPREFELPGEDAIIRKEGSRLIIEPARPRSLLAVLKTWEPLDEEIGPIEDLPAEPVDI

Download         Length: 234 bp

>AT145570 NZ_CP062406:c2274519-2274459 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J9FLQ9

References