Detailed information of TA system TA145569

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 371335..372032
• Replicon: chromosome
• Accession: NZ_CP047218
• Organism: Sphingobium yanoikuyae strain YC-JY1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GS397_RS01920
• Protein ID: WP_159365512.1
• Coordinates: 371601..372032 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GS397_RS01915
• Protein ID: WP_159365511.1
• Coordinates: 371335..371604 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GS397_RS01885	367815..368195	+	381	WP_159365506.1	hypothetical protein	-
GS397_RS01890	368607..369116	-	510	WP_159365507.1	hypothetical protein	-
GS397_RS27790	369113..369331	-	219	Protein_375	DUF3380 domain-containing protein	-
GS397_RS01900	369857..370396	-	540	WP_159365508.1	AAA family ATPase	-
GS397_RS01905	370847..371086	+	240	WP_159365509.1	AlpA family phage regulatory protein	-
GS397_RS01910	371073..371285	+	213	WP_159365510.1	hypothetical protein	-
GS397_RS01915	371335..371604	+	270	WP_159365511.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GS397_RS01920	371601..372032	+	432	WP_159365512.1	type II toxin-antitoxin system VapC family toxin	Toxin
GS397_RS01925	372032..373672	+	1641	WP_159365513.1	recombinase family protein	-
GS397_RS01930	373699..374799	-	1101	WP_004211023.1	LPS export ABC transporter permease LptG	-
GS397_RS01935	374804..376015	-	1212	WP_004211025.1	LPS export ABC transporter permease LptF	-
GS397_RS01940	376153..376647	+	495	WP_010337967.1	DUF2141 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	346748..372032	25284

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-62)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15860.04 Da
• Isoelectric Point: 4.6547

>T145569 WP_159365512.1 NZ_CP047218:371601-372032 [Sphingobium yanoikuyae]
MSFLLDTNIISEGAKPRPDPGVMDWLASVDEEELFLSVVSLAELRHGIERMGKGARQSGLDIWLTEQLAPRFEERLLSID
SITADLWGRIVNRAQGAGRPMGAMDAFIAAHAQQHELTLVTRNISDFEATGIRLFNPWTEGKA

Nucleotide

• Length: 432 bp

>T145569 NZ_CP062406:2243051-2243317 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10073.44 Da
• Isoelectric Point: 8.8908

>AT145569 WP_159365511.1 NZ_CP047218:371335-371604 [Sphingobium yanoikuyae]
MAVETHPDSWTVAQAKARLSEVIEKARREPQAITRHGKSAVVVVDAELWERVQRRQHRGSFADFLLTSPLRGSGLEVDRL
KDGVREIDL

Nucleotide

• Length: 270 bp

>AT145569 NZ_CP062406:2242794-2243051 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA