145556

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 24385..25295 Replicon plasmid unnamed1
Accession NZ_CP047193
Organism Klebsiella pneumoniae strain Kp36

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag GS419_RS27070 Protein ID WP_004026354.1
Coordinates 24825..25295 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag GS419_RS27065 Protein ID WP_004026357.1
Coordinates 24385..24828 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS419_RS27040 19894..20796 + 903 WP_004213613.1 DMT family transporter -
GS419_RS27045 20939..21160 - 222 WP_004213615.1 hypothetical protein -
GS419_RS27050 21222..22529 - 1308 Protein_28 FepA family TonB-dependent siderophore receptor -
GS419_RS27055 22595..23575 + 981 WP_000019445.1 IS5-like element ISKpn26 family transposase -
GS419_RS27060 23781..24284 + 504 Protein_30 DUF4113 domain-containing protein -
GS419_RS27065 24385..24828 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
GS419_RS27070 24825..25295 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
GS419_RS27075 25444..26141 + 698 Protein_33 IS1 family transposase -
GS419_RS27080 27527..28476 - 950 Protein_34 DUF1173 family protein -
GS419_RS27085 28654..29148 + 495 WP_004212794.1 thermonuclease family protein -
GS419_RS27090 29485..29883 + 399 WP_004212796.1 H-NS histone family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA / iroN / rmpA2 / iutA / iucD / iucC / iucB / iucA 1..219800 219800
- inside IScluster/Tn - rmpA / iroN 11599..31334 19735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T145556 WP_004026354.1 NZ_CP047193:24825-25295 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T145556 NZ_CP062405:59750-59926 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT145556 WP_004026357.1 NZ_CP047193:24385-24828 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT145556 NZ_CP062405:c60088-59914 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References