145555

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5439094..5439719 Replicon chromosome
Accession NZ_CP047192
Organism Klebsiella pneumoniae strain Kp36

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag GS419_RS26545 Protein ID WP_002882817.1
Coordinates 5439094..5439477 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag GS419_RS26550 Protein ID WP_004150355.1
Coordinates 5439477..5439719 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS419_RS26530 5436460..5437362 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
GS419_RS26535 5437359..5437994 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
GS419_RS26540 5437991..5438920 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
GS419_RS26545 5439094..5439477 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
GS419_RS26550 5439477..5439719 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
GS419_RS26555 5439924..5440841 + 918 WP_002882812.1 alpha/beta hydrolase -
GS419_RS26560 5440855..5441796 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
GS419_RS26565 5441841..5442278 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
GS419_RS26570 5442275..5443135 - 861 WP_002882807.1 virulence factor BrkB family protein -
GS419_RS26575 5443129..5443728 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T145555 WP_002882817.1 NZ_CP047192:c5439477-5439094 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T145555 NZ_CP062405:18831-19007 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT145555 WP_004150355.1 NZ_CP047192:c5439719-5439477 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT145555 NZ_CP062405:c19169-18995 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References