Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 911232..911886 Replicon chromosome
Accession NZ_CP047192
Organism Klebsiella pneumoniae strain Kp36

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag GS419_RS04645 Protein ID WP_004144731.1
Coordinates 911479..911886 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GS419_RS04640 Protein ID WP_002916312.1
Coordinates 911232..911498 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS419_RS04615 906388..907821 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
GS419_RS04620 907940..908668 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GS419_RS04625 908718..909029 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
GS419_RS04630 909193..909852 + 660 WP_002916317.1 hemolysin III family protein -
GS419_RS04635 910003..910986 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
GS419_RS04640 911232..911498 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GS419_RS04645 911479..911886 + 408 WP_004144731.1 protein YgfX Toxin
GS419_RS04650 911893..912414 - 522 WP_002916308.1 flavodoxin FldB -
GS419_RS04655 912515..913411 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GS419_RS04660 913434..914147 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GS419_RS04665 914153..915886 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T145541 WP_004144731.1 NZ_CP047192:911479-911886 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T145541 NZ_CP062403:2304258-2304365 [Staphylococcus aureus]
ATCTTCAATTTATTAATTGACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCAAATTGGTTACGAAC
GCGCAGCAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT145541 WP_002916312.1 NZ_CP047192:911232-911498 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT145541 NZ_CP062403:c2304442-2304382 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References