Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2509915..2510526 Replicon chromosome
Accession NZ_CP047171
Organism Xylella fastidiosa subsp. fastidiosa strain IVIA5235

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag D1605_RS11110 Protein ID WP_011098375.1
Coordinates 2510227..2510526 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag D1605_RS11105 Protein ID WP_004085003.1
Coordinates 2509915..2510223 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1605_RS11075 2506494..2507255 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
D1605_RS11100 2508447..2509841 + 1395 WP_187120439.1 hypothetical protein -
D1605_RS11105 2509915..2510223 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
D1605_RS11110 2510227..2510526 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1605_RS11115 2510614..2511159 + 546 WP_011098376.1 hypothetical protein -
D1605_RS11120 2511171..2511314 + 144 WP_155115087.1 hypothetical protein -
D1605_RS11125 2511467..2511847 - 381 WP_004089371.1 DUF596 domain-containing protein -
D1605_RS11130 2511852..2512982 - 1131 WP_012382788.1 DUF769 domain-containing protein -
D1605_RS11135 2513290..2513670 - 381 WP_004087391.1 DUF596 domain-containing protein -
D1605_RS11140 2513682..2515256 - 1575 Protein_2168 DUF637 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2460707..2510976 50269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T145537 WP_011098375.1 NZ_CP047171:c2510526-2510227 [Xylella fastidiosa subsp. fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T145537 NZ_CP062403:123145-123297 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT145537 WP_004085003.1 NZ_CP047171:c2510223-2509915 [Xylella fastidiosa subsp. fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT145537 NZ_CP062403:122521-123120 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References