Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1577143..1577729 Replicon chromosome
Accession NZ_CP047171
Organism Xylella fastidiosa subsp. fastidiosa strain IVIA5235

Toxin (Protein)


Gene name hicA Uniprot ID Q87BV5
Locus tag D1605_RS07110 Protein ID WP_004089517.1
Coordinates 1577475..1577729 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B2I6C9
Locus tag D1605_RS07105 Protein ID WP_004085025.1
Coordinates 1577143..1577478 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1605_RS07075 1572742..1573596 - 855 WP_011098055.1 iron-sulfur cluster carrier protein ApbC -
D1605_RS07080 1574088..1574861 + 774 WP_004089528.1 3-deoxy-manno-octulosonate cytidylyltransferase -
D1605_RS07085 1574858..1575322 + 465 WP_011098056.1 low molecular weight phosphotyrosine protein phosphatase -
D1605_RS07090 1575309..1576022 - 714 WP_011098057.1 site-specific DNA-methyltransferase -
D1605_RS07095 1576373..1576654 + 282 WP_011098058.1 type II toxin-antitoxin system RelE/ParE family toxin -
D1605_RS07100 1576664..1576963 + 300 WP_004089519.1 HigA family addiction module antidote protein -
D1605_RS07105 1577143..1577478 - 336 WP_004085025.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
D1605_RS07110 1577475..1577729 - 255 WP_004089517.1 type II toxin-antitoxin system HicA family toxin Toxin
D1605_RS07115 1577782..1578480 - 699 WP_011098059.1 hypothetical protein -
D1605_RS07120 1578609..1579070 - 462 WP_011098060.1 hypothetical protein -
D1605_RS07125 1579067..1579831 - 765 WP_004090689.1 hypothetical protein -
D1605_RS07130 1579737..1580843 - 1107 WP_012382665.1 YdaU family protein -
D1605_RS07135 1580840..1581139 - 300 WP_080513037.1 hypothetical protein -
D1605_RS07140 1581138..1581615 + 478 Protein_1389 conjugal transfer protein -
D1605_RS07145 1581621..1582226 + 606 WP_187120436.1 conjugal transfer protein TrbN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9639.14 Da        Isoelectric Point: 11.2766

>T145536 WP_004089517.1 NZ_CP047171:c1577729-1577475 [Xylella fastidiosa subsp. fastidiosa]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Download         Length: 255 bp

>T145536 NZ_CP062403:20153-20329 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12324.07 Da        Isoelectric Point: 5.6556

>AT145536 WP_004085025.1 NZ_CP047171:c1577478-1577143 [Xylella fastidiosa subsp. fastidiosa]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Download         Length: 336 bp

>AT145536 NZ_CP062403:c20491-20317 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87BV5

Antitoxin

Source ID Structure
AlphaFold DB A0A060HAK5

References