Detailed information of TA system TA145533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1307835..1308366
• Replicon: chromosome
• Accession: NZ_CP047171
• Organism: Xylella fastidiosa subsp. fastidiosa strain IVIA5235

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q87CH1
• Locus tag: D1605_RS05820
• Protein ID: WP_004090909.1
• Coordinates: 1308085..1308366 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q87CH2
• Locus tag: D1605_RS05815
• Protein ID: WP_004090907.1
• Coordinates: 1307835..1308098 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1605_RS05790	1303061..1304239	-	1179	WP_011097931.1	phage tail sheath family protein	-
D1605_RS05795	1304304..1305896	-	1593	WP_012382617.1	tail fiber domain-containing protein	-
D1605_RS05800	1305904..1306461	-	558	WP_011097610.1	phage tail protein I	-
D1605_RS05805	1306454..1307347	-	894	WP_011097611.1	baseplate J/gp47 family protein	-
D1605_RS05810	1307347..1307685	-	339	WP_004090694.1	GPW/gp25 family protein	-
D1605_RS05815	1307835..1308098	+	264	WP_004090907.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
D1605_RS05820	1308085..1308366	+	282	WP_004090909.1	type II toxin-antitoxin system YafQ family toxin	Toxin
D1605_RS05825	1308403..1308990	-	588	WP_011097612.1	phage baseplate assembly protein V	-
D1605_RS05830	1308987..1309529	-	543	WP_011097613.1	hypothetical protein	-
D1605_RS05835	1309505..1310026	-	522	WP_011097614.1	hypothetical protein	-
D1605_RS05840	1310023..1310346	-	324	WP_012382618.1	hypothetical protein	-
D1605_RS05845	1310346..1310606	-	261	WP_012382619.1	hypothetical protein	-
D1605_RS05850	1310624..1312498	-	1875	WP_012382620.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1298149..1341144	42995

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10936.37 Da
• Isoelectric Point: 7.2205

>T145533 WP_004090909.1 NZ_CP047171:1308085-1308366 [Xylella fastidiosa subsp. fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Nucleotide

• Length: 282 bp

>T145533 NZ_CP062402:c2049946-2049737 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9495.95 Da
• Isoelectric Point: 5.6033

>AT145533 WP_004090907.1 NZ_CP047171:1307835-1308098 [Xylella fastidiosa subsp. fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Nucleotide

• Length: 264 bp

>AT145533 NZ_CP062402:c2050251-2049958 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Toxin

• AlphaFold DB: Q87CH1

Antitoxin

• AlphaFold DB: Q87CH2