Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | FicTA/Fic(toxin) |
| Location | 1216962..1217758 | Replicon | chromosome |
| Accession | NZ_CP047171 | ||
| Organism | Xylella fastidiosa subsp. fastidiosa strain IVIA5235 | ||
Toxin (Protein)
| Gene name | VbhT | Uniprot ID | Q87CQ8 |
| Locus tag | D1605_RS05320 | Protein ID | WP_004088112.1 |
| Coordinates | 1216962..1217573 (-) | Length | 204 a.a. |
Antitoxin (Protein)
| Gene name | VbhA | Uniprot ID | B2I551 |
| Locus tag | D1605_RS05325 | Protein ID | WP_004088114.1 |
| Coordinates | 1217570..1217758 (-) | Length | 63 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D1605_RS05275 | 1212417..1213304 | - | 888 | WP_012382597.1 | YdaU family protein | - |
| D1605_RS05280 | 1213301..1214089 | - | 789 | WP_011097897.1 | Bro-N domain-containing protein | - |
| D1605_RS05285 | 1214086..1214718 | - | 633 | WP_004088094.1 | Bro-N domain-containing protein | - |
| D1605_RS05290 | 1214715..1214999 | - | 285 | WP_004088096.1 | hypothetical protein | - |
| D1605_RS05295 | 1214996..1215244 | - | 249 | WP_011097898.1 | hypothetical protein | - |
| D1605_RS05300 | 1215241..1215429 | - | 189 | WP_004088102.1 | hypothetical protein | - |
| D1605_RS05305 | 1215457..1215648 | - | 192 | WP_004088104.1 | hypothetical protein | - |
| D1605_RS05310 | 1215907..1216152 | - | 246 | WP_004088108.1 | hypothetical protein | - |
| D1605_RS05315 | 1216237..1216911 | + | 675 | WP_012382600.1 | helix-turn-helix transcriptional regulator | - |
| D1605_RS05320 | 1216962..1217573 | - | 612 | WP_004088112.1 | Fic/DOC family protein | Toxin |
| D1605_RS05325 | 1217570..1217758 | - | 189 | WP_004088114.1 | antitoxin VbhA family protein | Antitoxin |
| D1605_RS05330 | 1218150..1218686 | + | 537 | WP_012382601.1 | hypothetical protein | - |
| D1605_RS05335 | 1218683..1219096 | + | 414 | WP_004088056.1 | DUF1566 domain-containing protein | - |
| D1605_RS05340 | 1219093..1219494 | + | 402 | WP_004088054.1 | hypothetical protein | - |
| D1605_RS05345 | 1219491..1219640 | + | 150 | WP_012382602.1 | hypothetical protein | - |
| D1605_RS05350 | 1219726..1220004 | + | 279 | WP_004088050.1 | hypothetical protein | - |
| D1605_RS05355 | 1220027..1220218 | + | 192 | WP_012382603.1 | hypothetical protein | - |
| D1605_RS05360 | 1220239..1220583 | + | 345 | WP_004088346.1 | hypothetical protein | - |
| D1605_RS05365 | 1220623..1221444 | + | 822 | WP_004088345.1 | DUF2303 family protein | - |
| D1605_RS05370 | 1221460..1222386 | + | 927 | WP_004088344.1 | phage recombination protein Bet | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1170909..1227508 | 56599 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 204 a.a. Molecular weight: 22832.60 Da Isoelectric Point: 5.1271
>T145532 WP_004088112.1 NZ_CP047171:c1217573-1216962 [Xylella fastidiosa subsp. fastidiosa]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGGLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE
MKYAGDRGDPYLDSETGVLRNLLGIRDQGGLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE
Download Length: 612 bp
>T145532 NZ_CP062402:c2030358-2029996 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
Antitoxin
Download Length: 63 a.a. Molecular weight: 6837.77 Da Isoelectric Point: 4.9859
>AT145532 WP_004088114.1 NZ_CP047171:c1217758-1217570 [Xylella fastidiosa subsp. fastidiosa]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQIA
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQIA
Download Length: 189 bp
>AT145532 NZ_CP062402:c2030525-2030355 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|