Detailed information of TA system TA145527

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 651108..651729
• Replicon: chromosome
• Accession: NZ_CP047165
• Organism: Pelistega ratti strain NLN63

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F9B76_RS02680
• Protein ID: WP_159990704.1
• Coordinates: 651108..651407 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: F9B76_RS02685
• Protein ID: WP_159990705.1
• Coordinates: 651409..651729 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9B76_RS02665	646692..647981	-	1290	WP_159990701.1	adenosylmethionine--8-amino-7-oxononanoate transaminase	-
F9B76_RS02670	648242..648685	-	444	WP_159990702.1	hypothetical protein	-
F9B76_RS02675	649098..650447	+	1350	WP_159990703.1	NADP-specific glutamate dehydrogenase	-
F9B76_RS02680	651108..651407	+	300	WP_159990704.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F9B76_RS02685	651409..651729	+	321	WP_159990705.1	putative addiction module antidote protein	Antitoxin
F9B76_RS02690	651759..652001	+	243	WP_159990706.1	hypothetical protein	-
F9B76_RS02695	651970..652371	-	402	WP_159990707.1	tyrosine-type recombinase/integrase	-
F9B76_RS02700	652533..652670	-	138	WP_159990708.1	hypothetical protein	-
F9B76_RS02705	652712..652918	-	207	WP_159990709.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (48-91)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11358.21 Da
• Isoelectric Point: 10.1829

>T145527 WP_159990704.1 NZ_CP047165:651108-651407 [Pelistega ratti]
MYIINQTEDFEKWVSSIRDIKAKTTIAMRLRRAALGNLGNVKSLGGGVYEMKIDVGAGYRLYYGQEGKYIYLMFWGGNKS
TQEKDIKIARNLWKEIKGV

Nucleotide

• Length: 300 bp

>T145527 NZ_CP062401:2716757-2717119 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11776.58 Da
• Isoelectric Point: 6.4760

>AT145527 WP_159990705.1 NZ_CP047165:651409-651729 [Pelistega ratti]
MSNSRIKIKPVDISEYLDSEEMIEEYLKQAIEEGDPILLAHALADVAKARGMSEVAKKSGLSREGLYKALSGDTKPRYET
LQKVLGALGFGLSIKPLQKIENYHQI

Nucleotide

• Length: 321 bp

>AT145527 NZ_CP062401:2716590-2716760 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA