Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4691..5271 Replicon plasmid pKP19-2029-Col
Accession NZ_CP047162
Organism Klebsiella pneumoniae strain KP19-2029

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag GSU00_RS27795 Protein ID WP_071177730.1
Coordinates 4957..5271 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag GSU00_RS27790 Protein ID WP_000093040.1
Coordinates 4691..4969 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSU00_RS27760 751..900 - 150 WP_032440454.1 colicin release lysis protein -
GSU00_RS27765 985..1242 - 258 WP_032440455.1 cloacin -
GSU00_RS27770 1252..2937 - 1686 WP_032440457.1 cloacin -
GSU00_RS27775 3264..3509 + 246 WP_032440458.1 hypothetical protein -
GSU00_RS27780 3783..4154 + 372 WP_001237044.1 cell envelope integrity protein TolA -
GSU00_RS27785 4151..4357 + 207 Protein_5 TonB family protein -
GSU00_RS27790 4691..4969 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
GSU00_RS27795 4957..5271 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GSU00_RS27800 5435..5863 + 429 WP_001140599.1 hypothetical protein -
GSU00_RS27805 5889..6068 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
GSU00_RS27810 6095..6625 - 531 WP_071177729.1 hypothetical protein -
GSU00_RS27815 6632..7363 - 732 WP_071177728.1 replication-relaxation family protein -
GSU00_RS27820 7363..9327 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T145525 WP_071177730.1 NZ_CP047162:4957-5271 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T145525 NZ_CP062401:2638356-2638460 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT145525 WP_000093040.1 NZ_CP047162:4691-4969 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT145525 NZ_CP062401:c2638618-2638455 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References