Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5388903..5389419 Replicon chromosome
Accession NZ_CP047160
Organism Klebsiella pneumoniae strain KP19-2029

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag GSU00_RS26240 Protein ID WP_002886902.1
Coordinates 5388903..5389187 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GSU00_RS26245 Protein ID WP_002886901.1
Coordinates 5389177..5389419 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSU00_RS26220 5384387..5384695 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
GSU00_RS28420 5384780..5384953 + 174 WP_002886906.1 hypothetical protein -
GSU00_RS26225 5384956..5385699 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GSU00_RS26230 5386056..5388194 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
GSU00_RS26235 5388435..5388899 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GSU00_RS26240 5388903..5389187 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GSU00_RS26245 5389177..5389419 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GSU00_RS26250 5389497..5391407 - 1911 WP_004152270.1 BglG family transcription antiterminator -
GSU00_RS26255 5391430..5392584 - 1155 WP_002886900.1 lactonase family protein -
GSU00_RS26260 5392650..5393390 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T145517 WP_002886902.1 NZ_CP047160:c5389187-5388903 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T145517 NZ_CP062401:19379-19555 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT145517 WP_002886901.1 NZ_CP047160:c5389419-5389177 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT145517 NZ_CP062401:c19717-19543 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References